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S0309, Myeloma Specimen Repository Protocol, Ancillary

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Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Precancerous Condition

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Trial Information

S0309, Myeloma Specimen Repository Protocol, Ancillary


- Maintain and expand tissue repositories of myeloma specimens from uniformly treated
Southwest Oncology Group (SWOG) patients with multiple myeloma, smoldering myeloma,
Waldenstrom's macroglobulinemia, amyloidosis, or monoclonal gammopathy of undetermined

- Utilize scientific information generated from intergroup and collaborative studies to
assist the SWOG Myeloma Committee in the development of new and more effective
treatment regimens for these patients.

OUTLINE: Patients receive treatment as directed by the treatment protocols on which they are
registered. Specimens of blood and/or marrow are submitted to the Myeloma Repository. The
status of the patient (e.g., pre-study, post-remission, or relapse) will be recorded prior
to specimen collection.


Inclusion Criteria


- Diagnosis of 1 of the following:

- Multiple myeloma

- Smoldering myeloma

- Waldenstrom's macroglobulinemia

- Amyloidosis

- Monoclonal gammopathy of undetermined significance

- Must be currently registered on a Southwest Oncology Group-coordinated treatment
study (SWOG or Intergroup)

- Must have pretreatment specimens to submit to this study

- No cytogenetic samples


- Not specified


- Not specified

Type of Study:


Study Design:


Outcome Measure:

Maintenance and expansion of tissue repositories of myeloma specimens from uniformly treated SWOG patients with multiple myeloma, smoldering myeloma, Waldenstrom's macroglobulinemia, amyloidosis, or monoclonal gammopathy of undetermined significance

Outcome Time Frame:

7 years

Safety Issue:


Principal Investigator

Joshua Espstein, DSC

Investigator Role:

Study Chair

Investigator Affiliation:

University of Arkansas


United States: Federal Government

Study ID:




Start Date:

November 2003

Completion Date:

November 2010

Related Keywords:

  • Lymphoma
  • Multiple Myeloma and Plasma Cell Neoplasm
  • Precancerous Condition
  • multiple myeloma
  • Waldenström macroglobulinemia
  • monoclonal gammopathy of undetermined significance
  • primary systemic amyloidosis
  • Amyloidosis
  • Neoplasms
  • Lymphoma
  • Waldenstrom Macroglobulinemia
  • Monoclonal Gammopathy of Undetermined Significance
  • Paraproteinemias
  • Multiple Myeloma
  • Neoplasms, Plasma Cell
  • Plasmacytoma
  • Precancerous Conditions



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