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Assessment of Candidate Protein Expression in Human Breast Cancer Specimens


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Open (Enrolling)
Both
Breast Cancer

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Trial Information

Assessment of Candidate Protein Expression in Human Breast Cancer Specimens


OBJECTIVES:

- To determine if candidate genes display differential expression between normal and
cancer breast tissues.

OUTLINE: Previously collected breast cancer tissue samples (paraffin embedded blocks) and
normal adjacent tissue are used for immunohistochemistry studies of expression of candidate
genes.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of breast cancer

- Tissue samples available

- Samples are selected based on presence or absence of tumor receptors, (i.e.;
estrogen, progesterone, and HER2 receptors) and grouped into following 4 categories:

- Estrogen receptor (ER)-positive/progesterone receptor
(PR)-positive/HER2-negative

- ER-positive/PR-positive/ HER2-positive by FISH

- ER-negative/PR-negative/HER2-positive

- ER-negative/PR-negative/HER2-negative(triple negative or basal-type cancers)

PATIENT CHARACTERISTICS:

- Menopausal status not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

Time Perspective: Retrospective

Outcome Measure:

Differential expression of candidate genes between normal and cancer breast tissues

Outcome Description:

Approximately 5 slides of each tumor will be collected to provide sufficient samples for replicate staining, if necessary, as well as a staining for a positive control

Outcome Time Frame:

non-applicable

Safety Issue:

No

Principal Investigator

Ruth A. Keri, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center

Authority:

United States: Institutional Review Board

Study ID:

CASE1108

NCT ID:

NCT00918892

Start Date:

April 2008

Completion Date:

Related Keywords:

  • Breast Cancer
  • breast cancer
  • estrogen receptor-negative breast cancer
  • estrogen receptor-positive breast cancer
  • progesterone receptor-negative breast cancer
  • progesterone receptor-positive breast cancer
  • triple-negative breast cancer
  • HER2-negative breast cancer
  • HER2-positive breast cancer
  • Breast Neoplasms

Name

Location
Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center Cleveland, Ohio  44106-5065