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Impact of the Human Papillomavirus (HPV) Status in Carcinologic Prognosis of Oropharynx Squamous Cell Carcinoma.


N/A
18 Years
N/A
Open (Enrolling)
Both
Oropharyngeal Neoplasms

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Trial Information

Impact of the Human Papillomavirus (HPV) Status in Carcinologic Prognosis of Oropharynx Squamous Cell Carcinoma.


The study has no impact on the treatment of the observed population. The clinical study
include TNM status, previous story of HPV infection, smoking and alcoholic habits, treatment
and outcome during 2 years. The virologic study include : HPV type, E6-E7 viral charge of
HPV16, viral DNA integration in the tumoral genome, HPV16 variants, expression of HPV 16,
18, 31, 45 coding oncoproteins E6-E7 mRNA. Moreover a serologic study will be done.


Inclusion Criteria:



- Squamous cell carcinoma of Oropharynx proven histologically

- All stages TNM

- informed consent

- No previous or simultaneous Head Neck cancer

- Age >18

Exclusion Criteria:

- Squamous cell carcinoma other than oropharynx

- 2nd synchronous SCC localization

- No consent

- age < 18

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

DFS at 2 years in HPV + and - tumors

Outcome Time Frame:

at 2 years

Safety Issue:

No

Principal Investigator

Jean LACAU, PhD, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Assistance Publique - Hôpitaux de Paris

Authority:

France: French Data Protection Authority

Study ID:

AOM 08104

NCT ID:

NCT00918710

Start Date:

May 2009

Completion Date:

December 2014

Related Keywords:

  • Oropharyngeal Neoplasms
  • Squamous cell carcinoma of Oropharynx
  • Human papillomavirus.
  • Biological prognostic markers.
  • Neoplasms
  • Carcinoma
  • Carcinoma, Squamous Cell
  • Oropharyngeal Neoplasms

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