Impact of the Human Papillomavirus (HPV) Status in Carcinologic Prognosis of Oropharynx Squamous Cell Carcinoma.
The study has no impact on the treatment of the observed population. The clinical study
include TNM status, previous story of HPV infection, smoking and alcoholic habits, treatment
and outcome during 2 years. The virologic study include : HPV type, E6-E7 viral charge of
HPV16, viral DNA integration in the tumoral genome, HPV16 variants, expression of HPV 16,
18, 31, 45 coding oncoproteins E6-E7 mRNA. Moreover a serologic study will be done.
Observational Model: Cohort, Time Perspective: Prospective
DFS at 2 years in HPV + and - tumors
at 2 years
Jean LACAU, PhD, MD
Assistance Publique - Hôpitaux de Paris
France: French Data Protection Authority