Inclusion Criteria:

- Female with HER2-positive disease

- 18 years of age or older

- ECOG greater or equal to 2

- Life expectancy greater or equal to 6 months

- Able to complete self administered quality of life evaluations and neurocognitive
testing

- Willing and able to comply with study instructions and commit to all clinic visits
for the duration of the study

- Women of child-bearing potential must have a negative serum pregnancy test at
screening and a negative urine pregnancy test at the baseline visit and must use
highly effective birth control during study

- Signed informed consent form

Exclusion Criteria:

- Current malignancy in the brain, as determined by screening MRI/CT done no more then
6 weeks prior to study treatment with PCI

- Chemo or radiation planned during the period when patients will receive study
treatment with PCI

- Prior radiotherapy of the brain

- Prior stroke or brain hemorrhage in the 6 months prior to screening

- History of neurological/psychiatric disorders, including psychotic disorders or
demential, or any other reason, which may affect neurocognitive assessment

- Inadequate renal function

- Other known previous or concomitant serious illness or medical condition that may
interfere with participation in the study