Inclusion Criteria

DISEASE CHARACTERISTICS:

- Histologically confirmed solid tumor

- Locally advanced or metastatic disease

- Disease progressed on or after standard therapy OR there is no standard therapy for
the malignancy

- Standard therapy is defined as first- or second-line therapy that has been shown
to provide clinical benefit

- Life-long non-smoker

- No lung metastasis and/or pleural effusion causing signs or symptoms that impact
patient performance status

PATIENT CHARACTERISTICS:

- ECOG performance status 0-1

- Body mass index ≤ 35

- No concurrent uncontrolled illness including, but not limited to, the following:

- Ongoing or active infection

- Symptomatic congestive heart failure

- Unstable angina pectoris

- Ventricular arrhythmia

- Psychiatric illness or social situation that would limit compliance with study
requirements

- No uncontrolled chest or abdominal pain

- No oral or facial pain exacerbated by an oral device

- No stress incontinence

- No COPD, interstitial lung disease, pulmonary embolism, or hemorrhage within the past
6 months

- No history of pulmonary fibrosis or pulmonary hypertension

- No oxygen requirement at baseline

- No asthma

- No occupational lung disease, including, but not limited to, asbestos exposure

- No polycythemia

- No history of connective tissue disease

PRIOR CONCURRENT THERAPY:

- No prior radiotherapy to the lung

- At least 6 months since prior lung surgery

- No prior amiodarone hydrochloride

- No prior high-dose chemotherapy with autologous or allogeneic hematopoietic stem cell
transplantation

- No concurrent combination antiretroviral therapy for HIV-positive patients