Inclusion Criteria:

- Patients who have been diagnosed, by histologic and clinical examination, with
resected AJCC stage I or II melanoma.

- Patients who have any evidence of metastasis will not be eligible.

- All patients must have:

1. Karnofsky performance of 80% or higher

2. ECOG performance status of 0 or 1

3. Ability and willingness to give informed consent

- Laboratory parameters as follows:

1. ANC: 90% of lower limit of normal (LLN) to 120% of upper limit of normal (ULN)

2. Platelets: 100-500 x 103/uL

3. Hgb: 90% LLN to 120% ULN

4. Hepatic:

1. AST, ALT, Bilirubin, and Alk phos within normal limits,

2. LDH up to 1.2 x ULN

5. Renal:

1. Creatinine up to 1.5 x ULN

- Age 18-85 years at the time of study entry.

Exclusion Criteria:

- Patients who are currently receiving cytotoxic chemotherapy, interferon, or radiation
or who have received this therapy within the preceding 12 weeks.

- Patients with known or suspected allergies to any component of the vaccine.

- Patients receiving the following medications at study entry or within the preceding 4
weeks are excluded:

- Agents with putative immunomodulating activity (with the exception of
non-steroidal anti-inflammatory agents),

- Allergy desensitization injections,

- Corticosteroids, administered parenterally or orally. Topical corticosteroids
are acceptable.

- Any growth factors, Interleukin-2 or other interleukins.

- Pregnancy or the possibility of becoming pregnant during vaccine administration.
Female patients of child-bearing potential must have a negative pregnancy test
(urinary or serum beta-HCG) prior to administration of the injection.

- Patients in whom there is a medical contraindication or potential problem in
complying with the requirements of the protocol, in the opinion of the investigator.

- Patients classified according to the New York Heart Association classification as
having Class III or IV heart disease.

- Patients with serious symptomatic active pulmonary disease, with pleural effusions,
or with a history of pulmonary edema.

- Patients who have systemic autoimmune disease with visceral involvement.

- Patients with clinically apparent skin infection or other clinically evident
inflammation involving the skin adjacent to the melanoma biopsy scar.