Early Recognition of Pulmonary Arterial Hypertension in Myelodysplastic and Myeloproliferative Diseases
18 Years
95 Years
Both
Myeloproliferative Disorder, Myelodysplastic Syndromes, Pulmonary Hypertension
Trial Information
Early Recognition of Pulmonary Arterial Hypertension in Myelodysplastic and Myeloproliferative Diseases
For early recognition of pulmonary hypertension exercise doppler echocardiography will be
used in all patients. Patients with elevated pulmonary arterial pressure at rest or during
exercise (estimated by echocardiography), or with decreased exercise capacity (as a
potential sign of pulmonary hypertension) are advised to undergo right heart
catheterisation. Cardiopulmonary exercise testing and six-minute walk distance measurement
are performed to measure exercise capacity. The described work-up of patients allows precise
and objective hemodynamic and clinical evaluation.
Inclusion Criteria:
- myelodysplastic disease or myeloproliferative diseases
Exclusion Criteria:
- known pulmonary hypertension
- relevant pulmonary disease
- relevant left cardiac or valvular disease
- recent major operations
- recent changes in medications
- relevant anaemia
- inability to exercise
Type of Study:
Observational
Study Design:
Observational Model: Cohort, Time Perspective: Prospective
Outcome Measure:
mean pulmonary arterial pressure at rest and during exercise
Outcome Time Frame:
at baseline and after 1 year
Safety Issue:
No
Principal Investigator
Horst Olschewski, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Medical University of Graz, Pulmonology
Authority:
Austria: Federal Office for Safety in Health Care
Study ID:
20-097 ex 08/09
NCT ID:
NCT00909467
Start Date:
April 2009
Completion Date:
November 2011
Related Keywords:
- Myeloproliferative Disorder
- Myelodysplastic Syndromes
- Pulmonary Hypertension
- Hypertension, Pulmonary
- Hypertension
- Myelodysplastic Syndromes
- Preleukemia
- Myeloproliferative Disorders
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