Inclusion Criteria:

- Histologically confirmed adenocarcinoma of the prostate

- Inoperable prostate tumor or progradiated after surgery/ irradiation therapy

- Locally advanced tumor or distant metastases is present

Exclusion Criteria:

- Patient not fulfil the recruitment criteria

- Liver disease; Dubin-Johnson syndrome; Rotor syndrome; previous or existing liver
tumours (in carcinoma of the prostate only if these are not due to metastases);
wasting diseases (with the exception of carcinoma of the prostate); depression;
previous or existing thromboembolic processes; diabetes with vascular changes;
sickle-cell anaemia.

- As regards patients with prostatic carcinoma who have a history of thromboembolic
processes and/or an existing sickle-cell anaemia, or diabetes with vascular changes,
the risk:benefit ratio must be considered carefully in each individual case before
the use of Androcur