Prospective Randomized Phase III Trial Comparing Preoperative Chemoradiation Therapy (Cisplatin, 5-FU and Radiotherapy Followed by Surgery) to Surgery Followed by Postoperative Chemoradiation (Cisplatin, Epirubicin, 5-FU, Radiotherapy) for Esophageal Cancer
Patients will be randomized to neo-adjuvant or adjuvant treatment. Quality of life
questionnaires will be completed every 2 months up to 1 year.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
Quality of life as assessed by FACT-E
Richard Malthaner, MD
London Health Sciences Centre
Canada: Ethics Review Committee