Does Ultra Short-term Steroid Therapy Increase the Accuracy of FDG-PET/CT in Evaluation of Pulmonary Nodules?
- To determine whether ultra short-term steroid therapy (24-48 hours) can be used to
increase the accuracy of fludeoxyglucose F 18 positron emission tomography/computed
tomography (FDG-PET/CT) imaging in categorizing nodules in patients with pulmonary
- To calculate the overall sensitivity and specificity of the nodules group, based on FDG
uptake, for predicting malignancy.
- To gather effect-size estimates that will be used to improve the quality of a larger
OUTLINE: Patients receive oral dexamethasone at 40, 28, 16, and 4 hours before imaging.
Patients undergo fludeoxyglucose F 18 (FDG)-positron emission tomography/computed tomography
(PET/CT) imaging at baseline and upon completion of steroid therapy.
After completion of study therapy, patients are followed for 6 months.
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Feasibility of ultra short-term steroid therapy (24-48 hours) to increase the accuracy of FDG-PET/CT imaging
Majid Khalaf, MD
Barbara Ann Karmanos Cancer Institute
United States: Federal Government
|Barbara Ann Karmanos Cancer Institute||Detroit, Michigan 48201|
|Sinai-Grace Hospital||Detroit, Michigan 48235|