A Prospective Randomized Trial on Different Preoperative Radiotherapy Regimens in Rectal Cancer, Stockholm III.
Preoperative radiotherapy (RT) is recommended to many patients with localised rectal cancer,
not previously treated with pelvic RT. However, the optimum fractionation, the timing of
surgery and the best use of concomitant chemotherapy remains controversial. Short-course,
preoperative RT may induce both acute and late morbidity and has been claimed to cause more
morbidity than long-course preoperative RT. There are theoretical reasons to believe that RT
given in larger fractions during a shorter period of time might result in more late side
effects than giving a conventional, more protracted RT. In addition, the optimum timing of
surgery after RT, with respect to postoperative morbidity, mortality and potential
downsizing of the tumour is not known.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
time to recurrence
Anna Martling, PhD
Sweden: The National Board of Health and Welfare