Inclusion Criteria:

1. Patients with pathologically confirmed advanced or metastatic cancer that is
refractory to standard therapy, relapsed after standard therapy, or who have had no
standard therapy that induces a CR rate of at least 10% or improves survival by at
least three months.

2. Patients must have tumor tissue available, either from an archival specimen, or from
a recent biopsy, to be analyzed for EGFR mutation. Patients must sign consent for the
umbrella protocol prior testing for EGFR mutation. Patients will be eligible if they
have an EGFR-sensitive mutation, OR if they have an EGFR-resistant mutation, OR if
they do not have an EGFR mutation, but have benefited from EGFR inhibitor therapy
(including either >/= 4 months of stable disease [SD] OR a >/= partial response
[PR]).

3. Measurable or non-measurable disease.

4. Patients must be >/= 6 wks beyond treatment with a nitrosourea or mitomycin-C, >/= 4
wks beyond other chemotherapy or XRT, and must have recovered to for any treatment-limiting toxicity resulting from prior therapy. (Exception:
patients may have received palliative low dose XRT one week before treatment provided
it is not given to the only targeted lesions).

5. (continued from above) Also, patients who have received non-chemotherapeutic
biological agents will need to wait at least 5 half-lives or 4 wks, whichever is
shorter, from the last day of treatment.

6. ECOG performance status /= 60%)

7. Patients must have normal organ and marrow function defined as: absolute neutrophil
count >/=1,000/mL; platelets >/=50,000/mL; creatinine bilirubin
8. Women of childbearing potential and men must agree to use adequate contraception
(hormonal or barrier method of birth control; abstinence) prior to study entry, for
the duration of study participation, and for 30 days after the last dose.

9. Ability to understand and the willingness to sign a written informed consent
document.

Exclusion Criteria:

1. Patients with uncontrolled concurrent illness, including but not limited to: ongoing
or active infection; altered mental status or psychiatric illness/social situations
that would limit compliance with study requirements and/or obscure study results.

2. Uncontrolled systemic vascular hypertension (systolic blood pressure > 140 mm Hg,
diastolic blood pressure > 90 mm Hg on medication).

3. Patients with clinically significant cardiovascular disease: history of CVA within 6
months, myocardial infarction or unstable angina within 6 months, or unstable angina
pectoris.

4. Patients with colorectal carcinoma with tumors that demonstrate a KRAS mutation.

5. Pregnant or lactating women

6. Patients with a history of bone marrow transplant within the previous two years

7. Patients with a known hypersensitivity to any of the components of the drug products.

8. Patients who will be on treatment arm consisting of erlotinib and dasatinib should
not be taking any drugs that are potent inhibitors or inducers of CYP34A

9. Patients unable to swallow oral medications or with pre-existing gastrointestinal
disorders that might interfere with proper absorption of oral drugs.

10. Patients with major surgery within 30 days prior to entering the study.