Inclusion Criteria:

Urothelial Cancer Cases

- Must be ≥ 18 years of age AND

- Must have a diagnosis of urothelial cancer AND

- Must be an English-speaker

Non-Cancer Control Group

- Must be ≥ 18 years of age AND

- Must not have cancer or a personal history of cancer, with the exception of skin
cancer. AND

- Must not be a blood relative of cases AND

- Must not be a blood relative of another control AND

- Must be an English-speaker

Family Member Control Group:

In select kindreds with a high prevalence of bladder cancer and/or very early onset
bladder cancer, first- and second-degree family members of probands may be contacted by
the MSKCC study team and invited to complete the questionnaire and submit a saliva sample.

- Must be ≥ 18 years of age AND

- Must be a blood relative of a case participant AND

- Must be an English-speaker

Exclusion Criteria:

- Have any condition, which in the opinion of the primary MSKCC clinician or
investigators precludes their ability to provide informed consent.