TRANSORCE (A Sub-Study of SORCE)
OBJECTIVES:
- Examine the relationship between tumor genotype, expression, and patient outcome.
- Examine the relationship between constitutional genotype and patient outcome.
OUTLINE: This is a multicenter study.
Patients undergo blood and/or tissue sample collection for laboratory studies. Laboratory
studies include generation of tissue microarrays; analysis of protein expression by
immunohistochemistry; tumor DNA extraction and whole genome amplification; detection of VHL
or other relevant gene mutations by direct sequencing; and constitutional (lymphocyte DNA)
genotyping by single nucleotide polymorphism analysis.
Observational
N/A
Relationship between tumor genotype, expression, and patient outcome
No
Timothy Eisen
Study Chair
Cancer Research UK at Cambridge Research Institute
Unspecified
CDR0000601175
NCT00900536
July 2007
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