TRANSORCE (A Sub-Study of SORCE)
- Examine the relationship between tumor genotype, expression, and patient outcome.
- Examine the relationship between constitutional genotype and patient outcome.
OUTLINE: This is a multicenter study.
Patients undergo blood and/or tissue sample collection for laboratory studies. Laboratory
studies include generation of tissue microarrays; analysis of protein expression by
immunohistochemistry; tumor DNA extraction and whole genome amplification; detection of VHL
or other relevant gene mutations by direct sequencing; and constitutional (lymphocyte DNA)
genotyping by single nucleotide polymorphism analysis.
Relationship between tumor genotype, expression, and patient outcome
Cancer Research UK at Cambridge Research Institute