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Central Lymphoma Repository Tissue Procurement Protocol

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Trial Information

Central Lymphoma Repository Tissue Procurement Protocol


- Establish a central lymphoma tissue repository of fresh snap-frozen tissue from
patients with previously untreated non-Hodgkin's lymphoma (NHL).

- Determine a standard set of procedures for routine acquisition, banking, and study of
these tissue samples.

- Correlate presently activated phenotyping studies and future projected molecular
studies of the DNA and RNA status of these tissue samples with clinical results.

- Correlate pretreatment phenotype or genotype of tissue samples from patients with
intermediate- or high-grade NHL with patient outcome, in terms of complete response
rate, time to progression, and survival.

- Correlate the lymphoma lineage (T-cell vs B-cell), loss of class II human
histocompatibility antigen status (HLA-DR-positive vs HLA-DR-negative), proliferative
index (as measured by Ki-67), and B- or T-cell antigen aberrancy (e.g., lack of Pan B
or T antigen expression) with outcome in patients with intermediate- or high-grade NHL.

OUTLINE: Patients are treated on the SWOG study on which they are enrolled.

Tissue samples obtained before treatment began are banked in a tissue repository.

Samples from patients with intermediate- or high-grade non-Hodgkin's lymphoma are analyzed
by three-stage immunohistochemistry using monoclonal antibodies to B-cell antigens, T-cell
antigens, immunoglobulins, CALLA, HLA-DR, anti-interleukin-2 receptor, and Ki-67 (for the
proliferative index). Phenotype (immune marker status, proliferation status, and activation
status) is correlated with response to treatment, relapse, and overall survival.

PROJECTED ACCRUAL: Approximately 495 patients will be accrued for this study.

Inclusion Criteria


- Registered on an active Southwest Oncology Group (SWOG)-coordinated treatment
protocol for previously untreated non-Hodgkin's lymphoma

- Adequate pretreatment diagnostic tissue available meeting the following requirements:

- Fresh snap-frozen pretreatment diagnostic biopsy from any site (initial biopsy
or rebiopsy)

- 1 Hematoxylin and Eosin stained slide

- 1 paraffin block and surgery pathology report


- Not specified


- See Disease Characteristics

Type of Study:


Study Design:


Outcome Measure:

Establishment of a central lymphoma tissue repository of fresh snap-frozen tissue from patients with previously untreated non-Hodgkin's lymphoma (NHL)

Outcome Description:

feasibility of collecting specimens

Outcome Time Frame:

July 2011

Safety Issue:


Principal Investigator

Lisa Rimsza, MD

Investigator Role:

Study Chair

Investigator Affiliation:

University of Arizona


United States: Federal Government

Study ID:




Start Date:

February 1989

Completion Date:

October 2011

Related Keywords:

  • Lymphoma
  • stage I adult diffuse large cell lymphoma
  • stage I adult diffuse mixed cell lymphoma
  • stage I adult diffuse small cleaved cell lymphoma
  • stage II adult diffuse large cell lymphoma
  • stage II adult diffuse mixed cell lymphoma
  • stage II adult diffuse small cleaved cell lymphoma
  • stage III adult diffuse large cell lymphoma
  • stage III adult diffuse mixed cell lymphoma
  • stage III adult diffuse small cleaved cell lymphoma
  • stage IV adult diffuse large cell lymphoma
  • stage IV adult diffuse mixed cell lymphoma
  • stage IV adult diffuse small cleaved cell lymphoma
  • stage I grade 3 follicular lymphoma
  • stage II grade 3 follicular lymphoma
  • stage III grade 3 follicular lymphoma
  • stage IV grade 3 follicular lymphoma
  • stage I adult immunoblastic large cell lymphoma
  • stage II adult immunoblastic large cell lymphoma
  • stage III adult immunoblastic large cell lymphoma
  • stage IV adult immunoblastic large cell lymphoma
  • stage I adult lymphoblastic lymphoma
  • stage II adult lymphoblastic lymphoma
  • stage III adult lymphoblastic lymphoma
  • stage IV adult lymphoblastic lymphoma
  • stage I adult Burkitt lymphoma
  • stage II adult Burkitt lymphoma
  • stage III adult Burkitt lymphoma
  • stage IV adult Burkitt lymphoma
  • Lymphoma
  • Lymphoma, Non-Hodgkin
  • Lymphoma, Large-Cell, Immunoblastic



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