Nutrition Modulated Metabolism as a Disease Risk Factor
N/A
N/A
Female
Breast Cancer
Trial Information
Nutrition Modulated Metabolism as a Disease Risk Factor
OBJECTIVES:
- To complete characterization of metabolic serotypes based on the metabolome, and to
adapt these profiles for human epidemiological studies.
- To determine the extent to which metabolic profiles that are reflective of or
independent of long-term caloric intake predict breast cancer risk in nested
case-control studies.
- To identify critical serum metabolites.
OUTLINE: Laboratory studies, including metabolome profiling by high performance liquid
chromatography; and small molecule identification by mass spectroscopy, are performed on
previously collected blood samples.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Meets 1 of the following criteria:
- Confirmed breast cancer that was diagnosed at least 2 years after blood sample
collection (case)
- No prior diagnosis of cancer
- Healthy participant (control)
- Enrolled in the Nurses' Health Study
- Banked blood samples available
- Hormone receptor status not specified
PATIENT CHARACTERISTICS:
- Menopausal status not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
Observational Model: Cohort
Outcome Measure:
Generation of metabolome profiles that reflect nutritional status
Outcome Time Frame:
ongoing
Safety Issue:
No
Principal Investigator
Bruce S. Kristal, PhD
Investigator Role:
Study Chair
Investigator Affiliation:
Brigham and Women's Hospital
Authority:
United States: Institutional Review Board
Study ID:
CDR0000583255
NCT ID:
NCT00900367
Start Date:
July 2005
Completion Date:
Related Keywords:
- Breast Cancer
- breast cancer
- Breast Neoplasms
Name | Location |
|---|---|
| Dana-Farber/Brigham and Women's Cancer Center | Boston, Massachusetts 02115 |
