Nutrition Modulated Metabolism as a Disease Risk Factor
- To complete characterization of metabolic serotypes based on the metabolome, and to
adapt these profiles for human epidemiological studies.
- To determine the extent to which metabolic profiles that are reflective of or
independent of long-term caloric intake predict breast cancer risk in nested
- To identify critical serum metabolites.
OUTLINE: Laboratory studies, including metabolome profiling by high performance liquid
chromatography; and small molecule identification by mass spectroscopy, are performed on
previously collected blood samples.
Observational Model: Cohort
Generation of metabolome profiles that reflect nutritional status
Bruce S. Kristal, PhD
Brigham and Women's Hospital
United States: Institutional Review Board
|Dana-Farber/Brigham and Women's Cancer Center||Boston, Massachusetts 02115|