LABORATORY STUDIES OF SOFT TISSUE SARCOMAS
- To develop a pilot program for the collection, archiving, and experimental analyses of
soft tissue sarcomas (STS).
- To obtain STS tumors from cancer patients undergoing tumor removal or core needle
- To evaluate cellular and molecular factors involved in STS oncogenesis by studying
samples derived from human tumor specimens.
- To develop an accompanying bioinformatics database of the demographics of STS patients
from which tumor specimens are derived for experimental study.
OUTLINE: Tumor tissue samples are analyzed for gene and protein expression by cDNA
microarray analysis, RT-PCR, immunohistochemistry, in vitro transformation assays, RNA
interference, and Western blot or immunoprecipitation.
Observational Model: Case-Only, Time Perspective: Prospective
Identification of molecular targets that would improve the diagnosis, prognosis, and/or treatment of STS
Lee D. Cranmer, MD, PhD
University of Arizona
United States: Food and Drug Administration
|Arizona Cancer Center at University of Arizona Health Sciences Center||Tucson, Arizona 85724|