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LABORATORY STUDIES OF SOFT TISSUE SARCOMAS


N/A
N/A
N/A
Open (Enrolling)
Both
Sarcoma

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Trial Information

LABORATORY STUDIES OF SOFT TISSUE SARCOMAS


OBJECTIVES:

- To develop a pilot program for the collection, archiving, and experimental analyses of
soft tissue sarcomas (STS).

- To obtain STS tumors from cancer patients undergoing tumor removal or core needle
biopsies.

- To evaluate cellular and molecular factors involved in STS oncogenesis by studying
samples derived from human tumor specimens.

- To develop an accompanying bioinformatics database of the demographics of STS patients
from which tumor specimens are derived for experimental study.

OUTLINE: Tumor tissue samples are analyzed for gene and protein expression by cDNA
microarray analysis, RT-PCR, immunohistochemistry, in vitro transformation assays, RNA
interference, and Western blot or immunoprecipitation.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Meets one of the following criteria:

- Patients with soft tissue sarcoma (STS) undergoing evaluation, treatment, and/or
follow-up at the Arizona Cancer Center or University Medical Center

- Patients undergoing surgical treatment for STS removal or core needle biopsy for
medically indicated diagnostic or therapeutic purposes

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Outcome Measure:

Identification of molecular targets that would improve the diagnosis, prognosis, and/or treatment of STS

Outcome Time Frame:

3 months

Safety Issue:

No

Principal Investigator

Lee D. Cranmer, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Arizona

Authority:

United States: Food and Drug Administration

Study ID:

05-0509-04

NCT ID:

NCT00900341

Start Date:

August 2005

Completion Date:

Related Keywords:

  • Sarcoma
  • adult soft tissue sarcoma
  • childhood soft tissue sarcoma
  • Sarcoma

Name

Location
Arizona Cancer Center at University of Arizona Health Sciences Center Tucson, Arizona  85724