Retrospective Analysis of Endostatin Genotype in Prostate Cancer Patients to Assess the Association of a Single Nucleotide Polymorphism (D104N) in Endostatin and Prostate Cancer
- Determine the incidence of the D104N COL18A1 polymorphism in patients with prostate
- Determine the incidence of this polymorphism in African-American patients with prostate
OUTLINE: This is a retrospective, multicenter study.
DNA is extracted from preexisting serum samples and polymerase chain reaction is performed
to determine the genotype pattern.
PROJECTED ACCRUAL: A total of 500 patients and 250 healthy participants will be accrued for
Frequency of D104N COL18A1 polymorphism in patients with prostate cancer and in healthy participants
William D. Figg, PharmD
National Cancer Institute (NCI)
United States: Federal Government