Retrospective Analysis of Endostatin Genotype in Prostate Cancer Patients to Assess the Association of a Single Nucleotide Polymorphism (D104N) in Endostatin and Prostate Cancer
N/A
N/A
Male
Prostate Cancer
Trial Information
Retrospective Analysis of Endostatin Genotype in Prostate Cancer Patients to Assess the Association of a Single Nucleotide Polymorphism (D104N) in Endostatin and Prostate Cancer
OBJECTIVES:
Primary
- Determine the incidence of the D104N COL18A1 polymorphism in patients with prostate
cancer.
Secondary
- Determine the incidence of this polymorphism in African-American patients with prostate
cancer.
OUTLINE: This is a retrospective, multicenter study.
DNA is extracted from preexisting serum samples and polymerase chain reaction is performed
to determine the genotype pattern.
PROJECTED ACCRUAL: A total of 500 patients and 250 healthy participants will be accrued for
this study.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of prostate cancer OR healthy participant
- Patient enrolled on an IRB-approved clinical trial at the National Cancer Institute
or Northwestern University, including, but not limited to, any of the following:
- NCI-99-C-0052
- NCI-95-C-0178
- NCI-00-C-003
- NCI-00-C-0080
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Frequency of D104N COL18A1 polymorphism in patients with prostate cancer and in healthy participants
Safety Issue:
No
Principal Investigator
William D. Figg, PharmD
Investigator Role:
Study Chair
Investigator Affiliation:
National Cancer Institute (NCI)
Authority:
United States: Federal Government
Study ID:
CDR0000304552
NCT ID:
NCT00900185
Start Date:
Completion Date:
Related Keywords:
- Prostate Cancer
- recurrent prostate cancer
- stage I prostate cancer
- stage IIB prostate cancer
- stage IIA prostate cancer
- stage III prostate cancer
- stage IV prostate cancer
- Prostatic Neoplasms
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