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Pharmacodynamic Study of Fibroblast Activity Protein in Patients With Localized Pancreas Cancer Undergoing Surgical Resection


N/A
N/A
N/A
Open (Enrolling)
Both
Pancreatic Cancer

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Trial Information

Pharmacodynamic Study of Fibroblast Activity Protein in Patients With Localized Pancreas Cancer Undergoing Surgical Resection


OBJECTIVES:

Primary

- To assess the degree of fibroblast activation protein (FAP) enzymatic activity at the
tumor site in patients with localized pancreatic cancer.

Secondary

- To explore correlations between tumor stromal FAP enzymatic activity and stromal
α_2-antiplasmin levels.

- To explore correlations between tumor FAP enzymatic activity and plasma dipeptidyl
peptidase and plasma α_2-antiplasmin converting enzyme activity as potential
surrogates.

OUTLINE: Patients undergo fine-needle aspiration of tumor or suspected mass at baseline.
Tumor samples are analyzed by IHC for fibroblast activation protein (FAP) expression,
immunocapture assay for ex vivo FAP enzymatic activity, and western analysis for FAP
concentrations. Blood samples are collected weekly and analyzed for dipeptidyl peptidase
activity by ELISA and α_2-antiplasmin converting enzyme.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Biopsy-proven adenocarcinoma of the pancreas or pancreatic mass suspicious for
pancreatic cancer

- Localized disease

- Scheduled to undergo a resection or exploration of their pancreatic tumor

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Independence of tumor fibroblast activation protein (FAP) activity and Met-α2-antiplasmin expression

Safety Issue:

No

Principal Investigator

Jonathan Cheng, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Fox Chase Cancer Center

Authority:

Unspecified

Study ID:

CDR0000579635

NCT ID:

NCT00900016

Start Date:

August 2007

Completion Date:

Related Keywords:

  • Pancreatic Cancer
  • adenocarcinoma of the pancreas
  • recurrent pancreatic cancer
  • stage I pancreatic cancer
  • stage II pancreatic cancer
  • Pancreatic Neoplasms

Name

Location

Fox Chase Cancer Center - Philadelphia Philadelphia, Pennsylvania  19111-2497