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Renal Cell Cancer Tumor Markers


N/A
N/A
N/A
Not Enrolling
Both
Kidney Cancer

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Trial Information

Renal Cell Cancer Tumor Markers


OBJECTIVES:

Primary

- Determine the expression levels of novel genes and proteins (HFARP, HAMGR28, HE9NG77)
in frozen normal tissue and tumor tissue samples from patients who have undergone
nephrectomy for renal cell cancer.

- Correlate gene and protein expression levels with disease stage, tumor size, and
pathology reports (e.g., cell type, grade, and tissue architecture) in order to
evaluate the rate of gene and protein expression as targets for future therapeutic
interventions.

Secondary

- Compare proteomic screening of potential biomarkers using existing plasma and/or urine
samples from patients with renal cell cancer or breast cancer stored in the CCCWFU
Tumor Tissue Core with tissue samples from patients enrolled in this study.

OUTLINE: Normal and tumor tissue collected from patients who have undergone nephrectomy and
diagnostic and therapeutic intervention for renal cell cancer is analyzed for
histopathological expression and compared to normal kidney cells by northern blot. Tissue
samples are evaluated by RNA and protein extraction and analyzed by gel electrophoresis,
blotting, and phosphor-imaging for induction or suppression of genes and protein levels.
These data are correlated with clinical stage, tumor size, and histopathological grade and
architecture of the patient's disease.


Inclusion Criteria:



- Histologically confirmed renal cell cancer

- Clinical staging (if available)

- Underwent nephrectomy for renal cell cancer

Type of Study:

Observational

Study Design:

Time Perspective: Prospective

Outcome Measure:

Expression levels of novel genes and proteins (HFARP, HAMGR28, HE9NG77) in frozen normal tissue and tumor tissue

Outcome Time Frame:

day 1

Safety Issue:

No

Principal Investigator

Frank M. Torti, MD, MPH

Investigator Role:

Study Chair

Investigator Affiliation:

Comprehensive Cancer Center of Wake Forest University

Authority:

United States: Institutional Review Board

Study ID:

CDR0000550079

NCT ID:

NCT00899860

Start Date:

September 2003

Completion Date:

June 2012

Related Keywords:

  • Kidney Cancer
  • recurrent renal cell cancer
  • stage I renal cell cancer
  • stage II renal cell cancer
  • stage III renal cell cancer
  • stage IV renal cell cancer
  • Carcinoma, Renal Cell
  • Kidney Neoplasms

Name

Location

Wake Forest University Comprehensive Cancer CenterWinston-Salem, North Carolina  27157-1096