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Molecular and Genetic Markers in the Local-regional Management of Patients Undergoing Radiation Therapy


N/A
N/A
N/A
Not Enrolling
Both
Malignant Tumor of Lymphoid Hemopoietic and Related Tissue, Unspecified Adult Solid Tumor, Protocol Specific, Unspecified Childhood Solid Tumor, Protocol Specific

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Trial Information

Molecular and Genetic Markers in the Local-regional Management of Patients Undergoing Radiation Therapy


OBJECTIVES:

Primary

- Determine local-regional control in patients undergoing radiation therapy for cancer,
as a function of expression of specific molecular/genetic markers.

Secondary

- Determine complications of radiation therapy for patients undergoing radiation therapy
for cancer.

OUTLINE: Previously collected tissue samples are analyzed using immunohistochemical staining
and other molecular/genetic study methods to detect markers, including p53, cyclin D1,
HER-2-neu, bcl-2/BAX, and EGFR. Patient charts are also reviewed with emphasis on
local-regional relapse.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of cancer

- Undergoing radiation therapy for malignant disease

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Retrospective

Principal Investigator

Bruce G. Haffty, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Cancer Institute of New Jersey

Authority:

United States: Institutional Review Board

Study ID:

CDR0000592887

NCT ID:

NCT00899808

Start Date:

May 2006

Completion Date:

Related Keywords:

  • Malignant Tumor of Lymphoid Hemopoietic and Related Tissue
  • Unspecified Adult Solid Tumor, Protocol Specific
  • Unspecified Childhood Solid Tumor, Protocol Specific
  • unspecified adult solid tumor, protocol specific
  • unspecified childhood solid tumor, protocol specific
  • hematopoietic/lymphoid cancer
  • Neoplasms

Name

Location
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School New Brunswick, New Jersey  08903