Study of Mutations of Epidermal Growth Factor Receptor in the Blood of Patients With Advanced Non Small Cell Lung Cancer
- Determine if epidermal growth factor receptor (EGFR) mutation exists in the peripheral
blood of patients with advanced non-small cell lung cancer (NSCLC).
- Estimate the frequency of EGFR mutation in these patients.
- Correlate the presence of EGFR mutation in blood with EGFR mutation in primary or
metastatic NSCLC tumor block.
OUTLINE: Patients undergo blood collection for analysis of epidermal growth factor receptor
mutation by DNA sequencing.
PROJECTED ACCRUAL: A total of 50 patients will be accrued for this study.
Existence of epidermal growth factor receptor (EGFR) mutations in peripheral blood
Alex Y. Chang, MD
Johns Hopkins University