Study of Mutations of Epidermal Growth Factor Receptor in the Blood of Patients With Advanced Non Small Cell Lung Cancer
18 Years
N/A
Both
Lung Cancer
Trial Information
Study of Mutations of Epidermal Growth Factor Receptor in the Blood of Patients With Advanced Non Small Cell Lung Cancer
OBJECTIVES:
- Determine if epidermal growth factor receptor (EGFR) mutation exists in the peripheral
blood of patients with advanced non-small cell lung cancer (NSCLC).
- Estimate the frequency of EGFR mutation in these patients.
- Correlate the presence of EGFR mutation in blood with EGFR mutation in primary or
metastatic NSCLC tumor block.
OUTLINE: Patients undergo blood collection for analysis of epidermal growth factor receptor
mutation by DNA sequencing.
PROJECTED ACCRUAL: A total of 50 patients will be accrued for this study.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Histologically or cytologically confirmed advanced non-small cell lung cancer
- Must have available tumor tissue block
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Existence of epidermal growth factor receptor (EGFR) mutations in peripheral blood
Safety Issue:
No
Principal Investigator
Alex Y. Chang, MD
Investigator Role:
Study Chair
Investigator Affiliation:
Johns Hopkins University
Authority:
Unspecified
Study ID:
CDR0000491609
NCT ID:
NCT00899756
Start Date:
June 2006
Completion Date:
Related Keywords:
- Lung Cancer
- recurrent non-small cell lung cancer
- stage IIIA non-small cell lung cancer
- stage IIIB non-small cell lung cancer
- stage IV non-small cell lung cancer
- Carcinoma, Non-Small-Cell Lung
- Lung Neoplasms
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