Immunohistochemical Analysis of Human Transbronchial Biopsy Specimens Collected in a Phase I Chemoprevention Trial of Myo-Inositol in Heavy Smokers Conducted Outside the Intramural NCI Program
40 Years
74 Years
Both
Lung Cancer, Precancerous Condition
Trial Information
Immunohistochemical Analysis of Human Transbronchial Biopsy Specimens Collected in a Phase I Chemoprevention Trial of Myo-Inositol in Heavy Smokers Conducted Outside the Intramural NCI Program
OBJECTIVES:
- Determine the effect of inositol therapy on phoso-Akt levels in current or former
smokers with bronchial dysplastic lesions.
OUTLINE: Tissue samples collected on clinical trial BCCA-U98-0411 (before and after
treatment) are analyzed by immunohistochemistry for phospho-Akt levels.
PROJECTED ACCRUAL: A total of 20 patients will be accrued for this study.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of persistent bronchial dysplasia despite regular twice-daily treatment
with inhaled budesonide for 6 or 12 months on clinical trial BCCA-CIC-98-37
- Enrolled on clinical trial BCCA-U98-0411 to receive inositol
- Consented to tissue analysis in the original consent form
- Current or former smoker who has smoked at least 30 pack years
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Level of phospho-Akt by immunohistochemistry
Safety Issue:
No
Principal Investigator
Phillip Dennis, MD, PhD
Investigator Role:
Principal Investigator
Investigator Affiliation:
National Cancer Institute (NCI)
Authority:
United States: Federal Government
Study ID:
CDR0000434508
NCT ID:
NCT00899730
Start Date:
Completion Date:
Related Keywords:
- Lung Cancer
- Precancerous Condition
- non-small cell lung cancer
- squamous lung dysplasia
- Lung Neoplasms
- Precancerous Conditions
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