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The Molecular Epidemiology of de Novo and Treatment Related 11q23 Leukemia in the Young


N/A
N/A
21 Years
Not Enrolling
Both
Leukemia

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Trial Information

The Molecular Epidemiology of de Novo and Treatment Related 11q23 Leukemia in the Young


OBJECTIVES:

- Characterize the clinical, morphologic, immunologic, cytogenetic, and molecular
heterogeneity of acute lymphoblastic leukemia or acute myeloid leukemia (AML) in
infants and monoblastic variants of AML in young patients.

- Characterize the clinical, morphologic, immunologic, cytogenetic, and molecular
heterogeneity of secondary AML in young patients.

- Compare secondary AML vs de novo AML at the level of Southern blot, breakpoint
sequence, and DNA topoisomerase II cleavage sites.

OUTLINE: This is a multicenter study.

Bone marrow or blood are collected and analyzed by Southern blot for chromosome 11q23
breakpoints and translocations. Samples from patients with secondary acute myeloid leukemia
are also examined for MLL gene rearrangements.

PROJECTED ACCRUAL: A total of 250 patients will be accrued for this study.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of leukemia meeting 1 of the following criteria:

- Acute lymphoblastic leukemia OR acute myeloid leukemia (AML) (< 1 year of age at
diagnosis)

- M4 OR M5 AML (< 5 years of age at diagnosis)

- Secondary leukemia (< 21 years of age at diagnosis)

- Bone marrow sample, peripheral blood (WBC > 10,000/mm³ and 20% peripheral blasts), or
pheresis bag available

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Clinical, morphologic, immunologic, cytogenetic, and molecular characteristics of acute lymphoblastic leukemia and de novo and secondary acute myeloid leukemia (AML)

Safety Issue:

No

Principal Investigator

Beverly J. Lange, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Children's Hospital of Philadelphia

Authority:

United States: Federal Government

Study ID:

CDR0000538662

NCT ID:

NCT00899652

Start Date:

Completion Date:

Related Keywords:

  • Leukemia
  • childhood acute myelomonocytic leukemia (M4)
  • childhood acute monocytic leukemia (M5b)
  • childhood acute monoblastic leukemia (M5a)
  • secondary acute myeloid leukemia
  • untreated childhood acute lymphoblastic leukemia
  • untreated childhood acute myeloid leukemia and other myeloid malignancies
  • recurrent childhood acute lymphoblastic leukemia
  • recurrent childhood acute myeloid leukemia
  • Leukemia
  • Leukemia, Lymphoid
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Leukemia, Myeloid, Acute
  • Leukemia, Myeloid

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