Novel Colon Cancer Markers in Gastrointestinal Tissue and Biofluids
- Identify new potential biomarkers of increased gastrointestinal cancer risk using
tissue and biofluid samples from patients and healthy volunteers undergoing
colonoscopy, endoscopy, or surgery.
- Develop new screening strategies based on substances found in tissue and biofluid
OUTLINE: This is a multicenter study.
Patients and healthy volunteers undergo colonoscopy, endoscopy, or surgery. Patients and
healthy volunteers also undergo tissue (e.g., tumor or normal mucosa) and biofluid (e.g.,
blood, urine, cyst fluids or tumor cells, bile and pancreatic juices, and/or stool) sample
collection. Samples are analyzed for tumor markers by proteomic methods and protein
analysis. If candidate biomarkers are identified, samples are stored for future studies
involving these biomarkers. Information, including demographics, personal and family history
of cancer, and prior and current colonoscopy, endoscopy, or surgery results, is collected
from the medical record and stored in the project database.
Patients and healthy volunteers are followed once a year for up to 5 years to determine if
biomarkers have a prognostic significance.
Observational Model: Case Control, Time Perspective: Prospective
Identification of new potential biomarkers of increased gastrointestinal cancer risk using tissue and biofluid samples from patients and healthy volunteers undergoing colonoscopy, endoscopy, or surgery
Nipun B. Merchant
Vanderbilt-Ingram Cancer Center
United States: Institutional Review Board
|Vanderbilt-Ingram Cancer Center||Nashville, Tennessee 37232-6838|
|Veterans Affairs Medical Center - Nashville||Nashville, Tennessee 37212|
|Vanderbilt-Ingram Cancer Center - Cool Springs||Nashville, Tennessee 37064|
|Vanderbilt-Ingram Cancer Center at Franklin||Nashville, Tennessee 37064|