The Cancer Genome Atlas (TCGA) Utilizing Z0030 NSCLC Patient Samples
- To investigate the clinical relevance of conducting comprehensive molecular analyses on
clinically annotated high-quality tumor biospecimens from patients with stage I or II,
N0 or N1 (less than hilar) non-small cell lung cancer.
OUTLINE: This is a multicenter study.
Biological specimens are collected from participating clinical sites and analyzed by
transcription profiling of RNA and microRNA; detection of DNA copy number changes and
chromosomal rearrangements; epigenetic modifications analyses; and sequencing of genomic
segments, genes, and regulatory regions to assess sequence variation. Clinical information
associated with each specimen donor is also collected.
Clinical relevance of conducting comprehensive molecular analyses on clinically annotated high-quality tumor biospecimens
Mark S. Allen, MD