The Cancer Genome Atlas (TCGA) Utilizing Z0030 NSCLC Patient Samples
18 Years
N/A
Both
Lung Cancer
Trial Information
The Cancer Genome Atlas (TCGA) Utilizing Z0030 NSCLC Patient Samples
OBJECTIVES:
- To investigate the clinical relevance of conducting comprehensive molecular analyses on
clinically annotated high-quality tumor biospecimens from patients with stage I or II,
N0 or N1 (less than hilar) non-small cell lung cancer.
OUTLINE: This is a multicenter study.
Biological specimens are collected from participating clinical sites and analyzed by
transcription profiling of RNA and microRNA; detection of DNA copy number changes and
chromosomal rearrangements; epigenetic modifications analyses; and sequencing of genomic
segments, genes, and regulatory regions to assess sequence variation. Clinical information
associated with each specimen donor is also collected.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of non-small cell carcinoma
- Primary, untreated disease
- Stage I or II (T1 or T2, N0 or non-hilar N1, M0) disease
- Any of the following histologies allowed:
- Squamous cell carcinoma
- Adenocarcinoma (< 10%)
- Large cell carcinoma (high-grade)
- Available tumor tissue samples collected on clinical trial ACOSOG-Z0030 and meeting
the following criteria:
- Snap-frozen and stored at a temperature of -80°C or lower
- Specimens may come from any site within the lung or one that is involved by
direct regional extension of tumor from the originating site in the lung
- No regional lymph node or distant metastases
- No recurrent or persistent disease after prior neoadjuvant or adjuvant treatment for
lung cancer
- Must have matching frozen samples of normal tissue and blood
PATIENT CHARACTERISTICS:
- Not Specified
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Clinical relevance of conducting comprehensive molecular analyses on clinically annotated high-quality tumor biospecimens
Safety Issue:
No
Principal Investigator
Mark S. Allen, MD
Investigator Role:
Study Chair
Investigator Affiliation:
Mayo Clinic
Authority:
Unspecified
Study ID:
CDR0000617514
NCT ID:
NCT00899535
Start Date:
October 2008
Completion Date:
Related Keywords:
- Lung Cancer
- adenocarcinoma of the lung
- large cell lung cancer
- squamous cell lung cancer
- stage I non-small cell lung cancer
- stage II non-small cell lung cancer
- Carcinoma, Non-Small-Cell Lung
- Lung Neoplasms
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