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Molecular Mechanisms of NOTCH Induced Transformation in T-ALL


N/A
N/A
N/A
Not Enrolling
Both
Leukemia

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Trial Information

Molecular Mechanisms of NOTCH Induced Transformation in T-ALL


OBJECTIVES:

- Identify the transcriptional signatures associated with the presence of NOTCH1
mutations in primary T-cell acute lymphoblastic leukemia (T-ALL) cells using
oligonucleotide microarrays.

- Characterize the global changes on gene expression resulting from the inactivation of
NOTCH signaling in human T-ALL lymphoblasts.

OUTLINE: This is a multicenter study.

Frozen lymphoblast samples from patients with T-cell acute lymphoblastic leukemia
(NOTCH1-mutated and wild type) are assessed for genetic expression profiles and mutations by
microarray analysis and activated NOTCH1 protein by western blot analysis.

PROJECTED ACCRUAL: A total of 48 samples from patients will be accrued for this study.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Confirmed diagnosis of T-cell acute lymphoblastic leukemia

- Frozen lymphoblast samples available

- NOTCH1-mutated or wild type sample available

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Transcriptional signatures associated with NOTCH1 mutations in T-cell acute lymphoblastic leukemia (T-ALL) cells

Safety Issue:

No

Principal Investigator

Adolfo A. Ferrando, MD, PhD

Investigator Role:

Study Chair

Investigator Affiliation:

Herbert Irving Comprehensive Cancer Center

Authority:

Unspecified

Study ID:

CDR0000529758

NCT ID:

NCT00899366

Start Date:

December 2006

Completion Date:

Related Keywords:

  • Leukemia
  • T-cell adult acute lymphoblastic leukemia
  • T-cell childhood acute lymphoblastic leukemia
  • untreated adult acute lymphoblastic leukemia
  • untreated childhood acute lymphoblastic leukemia
  • recurrent adult acute lymphoblastic leukemia
  • recurrent childhood acute lymphoblastic leukemia
  • adult acute lymphoblastic leukemia in remission
  • childhood acute lymphoblastic leukemia in remission
  • Leukemia
  • Leukemia, Lymphoid
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

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