Molecular Mechanisms of NOTCH Induced Transformation in T-ALL
- Identify the transcriptional signatures associated with the presence of NOTCH1
mutations in primary T-cell acute lymphoblastic leukemia (T-ALL) cells using
- Characterize the global changes on gene expression resulting from the inactivation of
NOTCH signaling in human T-ALL lymphoblasts.
OUTLINE: This is a multicenter study.
Frozen lymphoblast samples from patients with T-cell acute lymphoblastic leukemia
(NOTCH1-mutated and wild type) are assessed for genetic expression profiles and mutations by
microarray analysis and activated NOTCH1 protein by western blot analysis.
PROJECTED ACCRUAL: A total of 48 samples from patients will be accrued for this study.
Transcriptional signatures associated with NOTCH1 mutations in T-cell acute lymphoblastic leukemia (T-ALL) cells
Adolfo A. Ferrando, MD, PhD
Herbert Irving Comprehensive Cancer Center