Protein Expression Profiles in Oropharyngeal Squamous Cell Carcinoma
- To investigate if some of the differences in gene expression are also reflected at the
- To determine whether differences in gene expression that are also reflected at the
protein level can be used to develop markers for early detection and disease
- To identify targets for therapy.
OUTLINE: Archived tumor tissue samples are analyzed for expression of standard
immunohistological markers (e.g., p16, p53, and Ki-67) as well as expression of genes
identified in a previous gene expression study. Protein expression data are tested for
clinical and demographic correlates and compared with gene expression data.
Observational Model: Case-Only, Time Perspective: Retrospective
Development of biomarkers for early detection or recurrence surveillance
after 7 months of tissue collection
Barbara Murphy, MD
Vanderbilt-Ingram Cancer Center
United States: Federal Government
VICC HN 0624