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Protein Expression Profiles in Oropharyngeal Squamous Cell Carcinoma


N/A
N/A
N/A
Not Enrolling
Both
Head and Neck Cancer

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Trial Information

Protein Expression Profiles in Oropharyngeal Squamous Cell Carcinoma


OBJECTIVES:

- To investigate if some of the differences in gene expression are also reflected at the
protein level.

- To determine whether differences in gene expression that are also reflected at the
protein level can be used to develop markers for early detection and disease
surveillance.

- To identify targets for therapy.

OUTLINE: Archived tumor tissue samples are analyzed for expression of standard
immunohistological markers (e.g., p16, p53, and Ki-67) as well as expression of genes
identified in a previous gene expression study. Protein expression data are tested for
clinical and demographic correlates and compared with gene expression data.


Inclusion Criteria:



- Diagnosis of squamous cell carcinoma of the oropharynx

- Tumor tissue samples available from Vanderbilt Head and Neck Tumor Repository and
Vanderbilt Pathology archives

Exclusion Criteria:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

Observational Model: Case-Only, Time Perspective: Retrospective

Outcome Measure:

Development of biomarkers for early detection or recurrence surveillance

Outcome Time Frame:

after 7 months of tissue collection

Safety Issue:

No

Principal Investigator

Barbara Murphy, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Vanderbilt-Ingram Cancer Center

Authority:

United States: Federal Government

Study ID:

VICC HN 0624

NCT ID:

NCT00899340

Start Date:

May 2006

Completion Date:

March 2008

Related Keywords:

  • Head and Neck Cancer
  • recurrent squamous cell carcinoma of the oropharynx
  • stage I squamous cell carcinoma of the oropharynx
  • stage II squamous cell carcinoma of the oropharynx
  • stage III squamous cell carcinoma of the oropharynx
  • stage IV squamous cell carcinoma of the oropharynx
  • Carcinoma, Squamous Cell
  • Head and Neck Neoplasms
  • Oropharyngeal Neoplasms

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