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Molecular and Functional Characterisation of Bone Marrow Function in Normal Subjects, Myelodysplastic Syndromes (MDS) and Secondary Disorders of Heamatopoiesis


N/A
18 Years
N/A
Open (Enrolling)
Both
Leukemia, Myelodysplastic Syndromes

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Trial Information

Molecular and Functional Characterisation of Bone Marrow Function in Normal Subjects, Myelodysplastic Syndromes (MDS) and Secondary Disorders of Heamatopoiesis


OBJECTIVES:

Primary

- To identify novel biomarkers of disease that would help in the initial diagnosis of
myelodysplastic syndromes (MDS).

Secondary

- To understand the genesis of anemia in cancers.

- To identify novel biomarkers of disease that predict progression of MDS to acute
myeloid leukemia.

OUTLINE: Blood and bone marrow samples are collected. Hemopoietic stem cells (HSC) and
progenitor cells are isolated from samples for analysis. Some of these HSC and progenitor
cells are used for functional assays. From the rest of the cells, DNA, RNA, and protein is
extracted for molecular analyses, including gene mutation analysis, gene methylation assays,
chromatin immunoprecipitation, microarray, and real-time polymerase chain reaction.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Must meet 1 of the following criteria:

- Being investigated for a potential blood disorder due to abnormal blood count

- Patients with a known blood disorder who are having a bone marrow sample taken
as part of the assessment of that disorder

- Patients undergoing hip replacement surgery at Nuffield Orthopaedic Centre,
Oxford meeting the following criteria:

- Not on treatment likely to impair bone marrow function

- No history of having had treatment likely to have impaired bone marrow
function

- Normal blood count

- Archived samples from patients with known blood disorder

PATIENT CHARACTERISTICS:

- See Disease Characteristics

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Identification of novel biomarkers of disease

Safety Issue:

No

Principal Investigator

Vyas Paresh, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Oxford Radcliffe Hospital

Authority:

Unspecified

Study ID:

CDR0000595855

NCT ID:

NCT00899327

Start Date:

January 2007

Completion Date:

Related Keywords:

  • Leukemia
  • Myelodysplastic Syndromes
  • myelodysplastic syndromes
  • acute myeloid leukemia
  • Leukemia
  • Myelodysplastic Syndromes
  • Preleukemia

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