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The Role of TAB3 Protein in Tumorigenesis


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Open (Enrolling)
Both
Non-melanomatous Skin Cancer, Pancreatic Cancer, Small Intestine Cancer, Testicular Germ Cell Tumor

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Trial Information

The Role of TAB3 Protein in Tumorigenesis


OBJECTIVES:

- To identify TAB3 transcript/protein as a molecular marker of cancer, specifically
testicular, skin, small intestine, and pancreatic cancer.

- To characterize TAB3 and its signaling networks that are involved in tumorigenesis.

OUTLINE: Tumor tissue samples from paraffin-embedded tissue blocks are analyzed for TAB3
transcript and protein expression using in situ hybridization and immunostaining with TAB3
cRNA probe and antibody. Antibodies against the proteins involved in the NFkB signaling
pathway (e.g., p65, TAK1, MyD88, and Akt) are used in the immunostaining assays.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Paraffin tissue blocks from surgical pathology cancer cases, specifically testicular,
skin, small intestine, and pancreatic cancer, available

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

Observational Model: Case-Only, Time Perspective: Cross-Sectional

Outcome Measure:

Identification of TAB3 transcript/protein as a molecular marker of cancer

Outcome Time Frame:

end of study

Safety Issue:

No

Principal Investigator

Ge Jin, PhD

Investigator Role:

Study Chair

Investigator Affiliation:

Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center

Authority:

United States: Institutional Review Board

Study ID:

CASE5Y06

NCT ID:

NCT00899132

Start Date:

February 2007

Completion Date:

Related Keywords:

  • Non-melanomatous Skin Cancer
  • Pancreatic Cancer
  • Small Intestine Cancer
  • Testicular Germ Cell Tumor
  • skin cancer
  • small intestine cancer
  • pancreatic cancer
  • malignant testicular germ cell tumor
  • testicular teratoma
  • Skin Neoplasms
  • Pancreatic Neoplasms
  • Testicular Neoplasms
  • Duodenal Neoplasms
  • Ileal Neoplasms
  • Jejunal Neoplasms
  • Neoplasms, Germ Cell and Embryonal
  • Intestinal Neoplasms

Name

Location
Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center Cleveland, Ohio  44106-5065