The Role of TAB3 Protein in Tumorigenesis
- To identify TAB3 transcript/protein as a molecular marker of cancer, specifically
testicular, skin, small intestine, and pancreatic cancer.
- To characterize TAB3 and its signaling networks that are involved in tumorigenesis.
OUTLINE: Tumor tissue samples from paraffin-embedded tissue blocks are analyzed for TAB3
transcript and protein expression using in situ hybridization and immunostaining with TAB3
cRNA probe and antibody. Antibodies against the proteins involved in the NFkB signaling
pathway (e.g., p65, TAK1, MyD88, and Akt) are used in the immunostaining assays.
Observational Model: Case-Only, Time Perspective: Cross-Sectional
Identification of TAB3 transcript/protein as a molecular marker of cancer
end of study
Ge Jin, PhD
Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center
United States: Institutional Review Board
|Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center||Cleveland, Ohio 44106-5065|