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Prediction of Overall Survival Using Mass Spectrometry Profiling in Head and Neck Cancer Patients Treated With Epidermal Growth Factor Receptor Inhibitors


N/A
18 Years
N/A
Not Enrolling
Both
Head and Neck Cancer

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Trial Information

Prediction of Overall Survival Using Mass Spectrometry Profiling in Head and Neck Cancer Patients Treated With Epidermal Growth Factor Receptor Inhibitors


OBJECTIVES:

- To validate the mass spectrometry profile that is predictive of survival benefit in
patients with recurrent or metastatic head and neck squamous cell carcinoma treated
with EGFR inhibitors.

OUTLINE: Plasma and serum samples are analyzed by matrix-assisted laser
desorption/ionization time-of-flight mass spectrometry and classified according to prognosis
("good" vs "poor") using a previously developed predictive algorithm.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of recurrent or metastatic head and neck squamous cell carcinoma

- Meets 1 of the following criteria:

- Enrolled on clinical trial ECOG-E3301 and previously treated with irinotecan
hydrochloride and docetaxel

- Enrolled on clinical trial VU-VICC-HN-0501 and previously treated with docetaxel
and bortezomib

- Plasma and serum samples available for analysis

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Overall survival measured in weeks

Safety Issue:

No

Principal Investigator

Christine Chung, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Vanderbilt-Ingram Cancer Center

Authority:

Unspecified

Study ID:

CDR0000600560

NCT ID:

NCT00898911

Start Date:

August 2008

Completion Date:

Related Keywords:

  • Head and Neck Cancer
  • recurrent squamous cell carcinoma of the hypopharynx
  • stage IV squamous cell carcinoma of the hypopharynx
  • stage IV squamous cell carcinoma of the larynx
  • stage IV verrucous carcinoma of the larynx
  • recurrent squamous cell carcinoma of the larynx
  • recurrent verrucous carcinoma of the larynx
  • recurrent squamous cell carcinoma of the lip and oral cavity
  • stage IV squamous cell carcinoma of the lip and oral cavity
  • recurrent verrucous carcinoma of the oral cavity
  • stage IV verrucous carcinoma of the oral cavity
  • metastatic squamous neck cancer with occult primary squamous cell carcinoma
  • recurrent metastatic squamous neck cancer with occult primary
  • recurrent squamous cell carcinoma of the nasopharynx
  • stage IV squamous cell carcinoma of the nasopharynx
  • recurrent squamous cell carcinoma of the oropharynx
  • stage IV squamous cell carcinoma of the oropharynx
  • recurrent squamous cell carcinoma of the paranasal sinus and nasal cavity
  • stage IV squamous cell carcinoma of the paranasal sinus and nasal cavity
  • recurrent salivary gland cancer
  • salivary gland squamous cell carcinoma
  • stage IV salivary gland cancer
  • Head and Neck Neoplasms

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