Trial Information
Prediction of Overall Survival Using Mass Spectrometry Profiling in Head and Neck Cancer Patients Treated With Epidermal Growth Factor Receptor Inhibitors
OBJECTIVES:
- To validate the mass spectrometry profile that is predictive of survival benefit in
patients with recurrent or metastatic head and neck squamous cell carcinoma treated
with EGFR inhibitors.
OUTLINE: Plasma and serum samples are analyzed by matrix-assisted laser
desorption/ionization time-of-flight mass spectrometry and classified according to prognosis
("good" vs "poor") using a previously developed predictive algorithm.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of recurrent or metastatic head and neck squamous cell carcinoma
- Meets 1 of the following criteria:
- Enrolled on clinical trial ECOG-E3301 and previously treated with irinotecan
hydrochloride and docetaxel
- Enrolled on clinical trial VU-VICC-HN-0501 and previously treated with docetaxel
and bortezomib
- Plasma and serum samples available for analysis
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Overall survival measured in weeks
Safety Issue:
No
Principal Investigator
Christine Chung, MD
Investigator Role:
Study Chair
Investigator Affiliation:
Vanderbilt-Ingram Cancer Center
Authority:
Unspecified
Study ID:
CDR0000600560
NCT ID:
NCT00898911
Start Date:
August 2008
Completion Date:
Related Keywords:
- Head and Neck Cancer
- recurrent squamous cell carcinoma of the hypopharynx
- stage IV squamous cell carcinoma of the hypopharynx
- stage IV squamous cell carcinoma of the larynx
- stage IV verrucous carcinoma of the larynx
- recurrent squamous cell carcinoma of the larynx
- recurrent verrucous carcinoma of the larynx
- recurrent squamous cell carcinoma of the lip and oral cavity
- stage IV squamous cell carcinoma of the lip and oral cavity
- recurrent verrucous carcinoma of the oral cavity
- stage IV verrucous carcinoma of the oral cavity
- metastatic squamous neck cancer with occult primary squamous cell carcinoma
- recurrent metastatic squamous neck cancer with occult primary
- recurrent squamous cell carcinoma of the nasopharynx
- stage IV squamous cell carcinoma of the nasopharynx
- recurrent squamous cell carcinoma of the oropharynx
- stage IV squamous cell carcinoma of the oropharynx
- recurrent squamous cell carcinoma of the paranasal sinus and nasal cavity
- stage IV squamous cell carcinoma of the paranasal sinus and nasal cavity
- recurrent salivary gland cancer
- salivary gland squamous cell carcinoma
- stage IV salivary gland cancer
- Head and Neck Neoplasms