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Central Lymphoma Repository Tissue Procurement Protocol for Relapse or Recurrent Disease

18 Years
Not Enrolling

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Trial Information

Central Lymphoma Repository Tissue Procurement Protocol for Relapse or Recurrent Disease


- Acquire fresh snap-frozen lymphoma tissue from patients with relapsed or recurrent
non-Hodgkin lymphoma after treatment on a Southwest Oncology Group (SWOG) clinical

- Establish a standard set of procedures for routine acquisition, banking, and study of
lymphoma tissues within the SWOG.

- Use repository tissue to establish clinical correlations via presently activated
phenotyping studies and future projected molecular studies assessing specimen DNA and
RNA status.

- Examine the biology of therapy failure in relationship to changes in pretreatment and
post-treatment immunophenotypic data.

OUTLINE: This is a multicenter study.

Tissues collected at biopsy are snap-frozen and archived for future molecular and genetic


Inclusion Criteria


- Diagnosis of relapsed or recurrent non-Hodgkin lymphoma (NHL)

- Previously registered on 1 of the following SWOG clinical trials for previously
untreated NHL:

- SWOG-8410

- SWOG-8503

- SWOG-8508

- SWOG-8516

- SWOG-8736

- SWOG-8809

- SWOG-8907

- SWOG-8954

- SWOG-9125

- SWOG-9240

- SWOG-9320

- SWOG-9349

- SWOG-9432

- SWOG-9501

- SWOG-9703

- SWOG-S9704

- SWOG-9800

- Tissue samples of relapsed or recurrent disease available


- Not specified


- See Disease Characteristics

Type of Study:


Study Design:

Time Perspective: Retrospective

Outcome Measure:

Acquisition of snap-frozen lymphoma tissues

Outcome Time Frame:

July 2011

Safety Issue:


Principal Investigator

Thomas Grogan, MD

Investigator Role:

Study Chair

Investigator Affiliation:

University of Arizona


United States: Federal Government

Study ID:




Start Date:

March 1993

Completion Date:

July 2011

Related Keywords:

  • Lymphoma
  • recurrent grade 3 follicular lymphoma
  • recurrent adult diffuse small cleaved cell lymphoma
  • recurrent adult diffuse mixed cell lymphoma
  • recurrent adult diffuse large cell lymphoma
  • recurrent adult immunoblastic large cell lymphoma
  • recurrent adult lymphoblastic lymphoma
  • recurrent adult Burkitt lymphoma
  • recurrent adult grade III lymphomatoid granulomatosis
  • recurrent grade 1 follicular lymphoma
  • recurrent grade 2 follicular lymphoma
  • recurrent mantle cell lymphoma
  • recurrent marginal zone lymphoma
  • recurrent small lymphocytic lymphoma
  • extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue
  • nodal marginal zone B-cell lymphoma
  • splenic marginal zone lymphoma
  • Waldenström macroglobulinemia
  • adult nasal type extranodal NK/T-cell lymphoma
  • recurrent childhood grade III lymphomatoid granulomatosis
  • recurrent childhood large cell lymphoma
  • recurrent childhood lymphoblastic lymphoma
  • recurrent childhood small noncleaved cell lymphoma
  • childhood diffuse large cell lymphoma
  • childhood immunoblastic large cell lymphoma
  • childhood Burkitt lymphoma
  • childhood nasal type extranodal NK/T-cell lymphoma
  • Lymphoma
  • Lymphoma, Non-Hodgkin
  • Lymphoma, Large-Cell, Immunoblastic



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