Identification of the Prognostic Factors of Stage II Colon Cancer Patients Receiving Adjuvant Chemotherapy With UFT
- Identify the prognostic factors in patients with curatively resected stage II colon
cancer receiving adjuvant chemotherapy with tegafur-uracil.
- Identify predictive factors of chemosensitivity to this regimen in these patients.
OUTLINE: Available tumor tissue samples are analyzed by real-time reverse transcriptase-PCR
for TS, DPD, TP, OPRT, VEGF, cyclooxygenase-2, and FPGS; by PCR for microsatellite
instability and genomic deletions on chromosome arm 18q; and pathologically for tumor
budding, Crohn's-like lymphoid reaction, category of extent of poor differentiation, and
fibrotic cancer stroma. The candidate prognostic and predictive markers are analyzed for
correlation with disease-free survival, relapse-free survival, and overall survival of
Kenichi Sugihara, MD, PhD
Tokyo Medical and Dental University
United States: Federal Government