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Molecular Detection of Circulating Cancer Cells in Breast, Ovarian, Colon and Pancreatic Cancer


N/A
N/A
N/A
Not Enrolling
Both
Breast Cancer, Colorectal Cancer, Ovarian Cancer, Pancreatic Cancer

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Trial Information

Molecular Detection of Circulating Cancer Cells in Breast, Ovarian, Colon and Pancreatic Cancer


OBJECTIVES:

- To assess frequency of circulating tumor cells (CTCs) in patients with metastatic
ovarian, breast, pancreatic, and colon cancers.

- To assess the variability in number of CTCs between patients with the same tumor type.

- To correlate the number of CTCs with extent of tumor burden as measured by tumor
markers, imaging, and the number of metastatic sites and proliferation and apoptotic
markers.

OUTLINE: Blood samples are collected before treatment and analyzed using molecular detection
techniques to detect circulating cancer cells. Samples are assessed by immunofluorescence
for markers of proliferation and survival (e.g., EGFR, phosphorylated EGFR, AKT,
phosphorylated AKT, cytokeratins, MAPK, Src, and FAK).

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Radiographic or marker evidence of metastatic ovarian, breast, pancreatic, or colon
disease

- Hormone receptor status not specified

PATIENT CHARACTERISTICS:

- Menopausal status not specified

- No history of any prior cancer

PRIOR CONCURRENT THERAPY:

- No prior therapy for metastatic disease

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Frequency of circulating cancer cells (CTC)

Outcome Time Frame:

1 day

Safety Issue:

No

Principal Investigator

Charles Erlichman, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Mayo Clinic

Authority:

United States: Federal Government

Study ID:

CDR0000582085

NCT ID:

NCT00898781

Start Date:

November 2007

Completion Date:

April 2010

Related Keywords:

  • Breast Cancer
  • Colorectal Cancer
  • Ovarian Cancer
  • Pancreatic Cancer
  • male breast cancer
  • stage IV breast cancer
  • stage IV ovarian epithelial cancer
  • stage IV ovarian germ cell tumor
  • stage IV pancreatic cancer
  • stage IV colon cancer
  • ovarian sarcoma
  • Breast Neoplasms
  • Colorectal Neoplasms
  • Ovarian Neoplasms
  • Pancreatic Neoplasms

Name

Location
Mayo Clinic Rochester, Minnesota  55905