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Genetic Analysis of Head and Neck Squamous Cell Carcinoma


N/A
18 Years
N/A
Not Enrolling
Both
Head and Neck Cancer

Thank you

Trial Information

Genetic Analysis of Head and Neck Squamous Cell Carcinoma


OBJECTIVES:

- Assess common genetic mutations in tumor and germline DNA samples from patients with
head and neck squamous cell carcinoma (HNSCC).

- Search for viral DNAs and relate this information to demographics, tumor
characteristics, and patient prognosis.

- Search for novel viral sequences and cancer-associated gene mutations in young
nonsmoking HNSCC patients and in other distinct head and neck cancers.

- Determine tumor suppressor gene mutations in HNSCC patients and relate this information
to gene expression data.

- Validate gene expression information using independent techniques such as real-time PCR
on expressed sequences and immunohistochemistry.

OUTLINE: Genetic mutation analysis and gene expression studies are performed on tissue
samples from patients with head and neck squamous cell carcinoma. Techniques used include
real time-PCR and immunohistochemistry.


Inclusion Criteria:



- Patient with head and neck squamous cell carcinoma (HNSCC) enrolled in the Head and
Neck Tissue Repository

- Sufficient biological material collected to perform study tests

- Historical material available from excess tissues at the Vanderbilt Pathology
Department

Exclusion Criteria:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Outcome Measure:

Assess common genetic mutations in tumor and germline DNA samples

Outcome Time Frame:

Upon collection of final patient data

Safety Issue:

No

Principal Investigator

Barbara Murphy, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Vanderbilt-Ingram Cancer Center

Authority:

United States: Federal Government

Study ID:

VICC HN 0625

NCT ID:

NCT00898664

Start Date:

June 2006

Completion Date:

April 2008

Related Keywords:

  • Head and Neck Cancer
  • stage I squamous cell carcinoma of the hypopharynx
  • stage II squamous cell carcinoma of the hypopharynx
  • stage III squamous cell carcinoma of the hypopharynx
  • stage IV squamous cell carcinoma of the hypopharynx
  • recurrent squamous cell carcinoma of the hypopharynx
  • stage I squamous cell carcinoma of the larynx
  • stage II squamous cell carcinoma of the larynx
  • stage III squamous cell carcinoma of the larynx
  • stage IV squamous cell carcinoma of the larynx
  • recurrent squamous cell carcinoma of the larynx
  • stage I squamous cell carcinoma of the lip and oral cavity
  • stage II squamous cell carcinoma of the lip and oral cavity
  • stage III squamous cell carcinoma of the lip and oral cavity
  • stage IV squamous cell carcinoma of the lip and oral cavity
  • recurrent squamous cell carcinoma of the lip and oral cavity
  • metastatic squamous neck cancer with occult primary squamous cell carcinoma
  • recurrent metastatic squamous neck cancer with occult primary
  • untreated metastatic squamous neck cancer with occult primary
  • stage I squamous cell carcinoma of the nasopharynx
  • stage II squamous cell carcinoma of the nasopharynx
  • stage III squamous cell carcinoma of the nasopharynx
  • stage IV squamous cell carcinoma of the nasopharynx
  • recurrent squamous cell carcinoma of the nasopharynx
  • stage I squamous cell carcinoma of the oropharynx
  • stage II squamous cell carcinoma of the oropharynx
  • stage III squamous cell carcinoma of the oropharynx
  • stage IV squamous cell carcinoma of the oropharynx
  • recurrent squamous cell carcinoma of the oropharynx
  • stage I squamous cell carcinoma of the paranasal sinus and nasal cavity
  • stage II squamous cell carcinoma of the paranasal sinus and nasal cavity
  • stage III squamous cell carcinoma of the paranasal sinus and nasal cavity
  • stage IV squamous cell carcinoma of the paranasal sinus and nasal cavity
  • recurrent squamous cell carcinoma of the paranasal sinus and nasal cavity
  • salivary gland squamous cell carcinoma
  • stage I salivary gland cancer
  • stage II salivary gland cancer
  • stage III salivary gland cancer
  • stage IV salivary gland cancer
  • recurrent salivary gland cancer
  • Carcinoma, Squamous Cell
  • Head and Neck Neoplasms

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