Trial Information
Genetic Analysis of Head and Neck Squamous Cell Carcinoma
OBJECTIVES:
- Assess common genetic mutations in tumor and germline DNA samples from patients with
head and neck squamous cell carcinoma (HNSCC).
- Search for viral DNAs and relate this information to demographics, tumor
characteristics, and patient prognosis.
- Search for novel viral sequences and cancer-associated gene mutations in young
nonsmoking HNSCC patients and in other distinct head and neck cancers.
- Determine tumor suppressor gene mutations in HNSCC patients and relate this information
to gene expression data.
- Validate gene expression information using independent techniques such as real-time PCR
on expressed sequences and immunohistochemistry.
OUTLINE: Genetic mutation analysis and gene expression studies are performed on tissue
samples from patients with head and neck squamous cell carcinoma. Techniques used include
real time-PCR and immunohistochemistry.
Inclusion Criteria:
- Patient with head and neck squamous cell carcinoma (HNSCC) enrolled in the Head and
Neck Tissue Repository
- Sufficient biological material collected to perform study tests
- Historical material available from excess tissues at the Vanderbilt Pathology
Department
Exclusion Criteria:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
Observational Model: Case-Only, Time Perspective: Prospective
Outcome Measure:
Assess common genetic mutations in tumor and germline DNA samples
Outcome Time Frame:
Upon collection of final patient data
Safety Issue:
No
Principal Investigator
Barbara Murphy, MD
Investigator Role:
Study Chair
Investigator Affiliation:
Vanderbilt-Ingram Cancer Center
Authority:
United States: Federal Government
Study ID:
VICC HN 0625
NCT ID:
NCT00898664
Start Date:
June 2006
Completion Date:
April 2008
Related Keywords:
- Head and Neck Cancer
- stage I squamous cell carcinoma of the hypopharynx
- stage II squamous cell carcinoma of the hypopharynx
- stage III squamous cell carcinoma of the hypopharynx
- stage IV squamous cell carcinoma of the hypopharynx
- recurrent squamous cell carcinoma of the hypopharynx
- stage I squamous cell carcinoma of the larynx
- stage II squamous cell carcinoma of the larynx
- stage III squamous cell carcinoma of the larynx
- stage IV squamous cell carcinoma of the larynx
- recurrent squamous cell carcinoma of the larynx
- stage I squamous cell carcinoma of the lip and oral cavity
- stage II squamous cell carcinoma of the lip and oral cavity
- stage III squamous cell carcinoma of the lip and oral cavity
- stage IV squamous cell carcinoma of the lip and oral cavity
- recurrent squamous cell carcinoma of the lip and oral cavity
- metastatic squamous neck cancer with occult primary squamous cell carcinoma
- recurrent metastatic squamous neck cancer with occult primary
- untreated metastatic squamous neck cancer with occult primary
- stage I squamous cell carcinoma of the nasopharynx
- stage II squamous cell carcinoma of the nasopharynx
- stage III squamous cell carcinoma of the nasopharynx
- stage IV squamous cell carcinoma of the nasopharynx
- recurrent squamous cell carcinoma of the nasopharynx
- stage I squamous cell carcinoma of the oropharynx
- stage II squamous cell carcinoma of the oropharynx
- stage III squamous cell carcinoma of the oropharynx
- stage IV squamous cell carcinoma of the oropharynx
- recurrent squamous cell carcinoma of the oropharynx
- stage I squamous cell carcinoma of the paranasal sinus and nasal cavity
- stage II squamous cell carcinoma of the paranasal sinus and nasal cavity
- stage III squamous cell carcinoma of the paranasal sinus and nasal cavity
- stage IV squamous cell carcinoma of the paranasal sinus and nasal cavity
- recurrent squamous cell carcinoma of the paranasal sinus and nasal cavity
- salivary gland squamous cell carcinoma
- stage I salivary gland cancer
- stage II salivary gland cancer
- stage III salivary gland cancer
- stage IV salivary gland cancer
- recurrent salivary gland cancer
- Carcinoma, Squamous Cell
- Head and Neck Neoplasms