Molecular Predictors of Lung Cancer Behavior
- To use fixed lung tissue for histological evaluation and fresh tissue samples for
molecular studies to study DNA, RNA, and protein abnormalities in lung preneoplastic
and neoplastic lesions.
- To use proteomic techniques, including matrix-assisted laser desorption ionization-mass
spectrometry (MALDI-MS), to develop a method of diagnosing and staging both
pre-invasive and invasive lesions, using less invasive methods.
OUTLINE: Blood, urine, nasal cell, and sputum samples are collected. Lung tissue samples are
also collected using fluorescence bronchoscopy and epithelial cell collection.
Samples are studied by genetic and proteomic analyses, including comparative genomic
hybridization, expression microarray, and protein profiling.
Observational Model: Cohort, Time Perspective: Prospective
To quantitate the molecular changes during lung cancer development
As a part of the study nasal brushing specimens, sputum, blood, urine, and a small amount of other tissue will be collected during standard of care procedures (bronchial epithelial, trans-thoracic fine needle aspiration (FNA) and thoracentesis as part of patient work up. Clinical diagnosis is the primary goal of the procedure. All the research specimens are collected after the primary goal of the procedure is met.
After collection of designated samples
Pierre P. Massion, MD
Vanderbilt-Ingram Cancer Center
Unites States: Vanderbilt University Human Reserach Protection Program
VICC THO 0398
|Vanderbilt-Ingram Cancer Center||Nashville, Tennessee 37232-6838|
|Veterans Affairs Medical Center - Nashville||Nashville, Tennessee 37212|
|Vanderbilt-Ingram Cancer Center - Cool Springs||Nashville, Tennessee 37064|
|Vanderbilt-Ingram Cancer Center at Franklin||Nashville, Tennessee 37064|