Prognostic Value of p53 and/or p16 Alterations in Ewing Sarcoma
- Determine if mutation of p53, and/or deletion of the p16 locus, have prognostic value
in patients with Ewing sarcoma.
- Estimate the incidence of p53 mutation in Ewing sarcoma samples collected from COG
- Estimate the incidence of p16 deletions in Ewing sarcoma samples collected from COG
- Prepare and archive amplified genomic DNA from Ewing sarcoma samples collected from COG
studies for future biologic analysis.
OUTLINE: This is a multicenter study.
Previously archived tumor samples are analyzed for p53 mutations and p16 deletion by
immunohistochemistry, FISH, PCR, and DNA sequencing.
Stephen Lessnick, MD, PhD
University of Utah
United States: Federal Government