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Evaluation of Cerebral Spinal Fluid (CSF) Proteome and Angiogenesis Proteins in Children With Newly Diagnosed Central Nervous System Tumors

21 Years
Not Enrolling
Brain and Central Nervous System Tumors

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Trial Information

Evaluation of Cerebral Spinal Fluid (CSF) Proteome and Angiogenesis Proteins in Children With Newly Diagnosed Central Nervous System Tumors



- Investigate the feasibility of centrally collecting and processing high-quality
cerebrospinal fluid (CSF) samples from pediatric patients with newly diagnosed central
nervous system tumors for proteomic studies.

- Identify protein markers that might indicate the presence of a brain tumor using CSF
samples collected from these patients.

OUTLINE: This is a multicenter study.

Patients undergo cerebrospinal fluid (CSF) collection from any or all of the following 5
sites: lumbar, cervical, ommaya, intra-operative (ventricular, cisternal), and/or external
ventricular drain. CSF is obtained within 8 weeks of diagnosis but prior to (or concurrent
with) the initiation of any post-operative therapy (excluding corticosteroids).

CSF samples are examined for proteomic biomarkers by 2D gel electrophoresis, low-mass
fingerprinting, and stable isotope labeling.

PROJECTED ACCRUAL: A total of 99 patients will be accrued for this study.

Inclusion Criteria


- Histologically confirmed CNS tumors of any of the following histologies:

- Diffuse pontine gliomas*

- Focal/infiltrative tumors, including any of the following:

- High- and low-grade gliomas

- Gangliogliomas

- Ependymomas

- Oligodendrogliomas

- Craniopharyngioma

- Dysembryoplastic neuroepithelial tumors

- Other low-grade neoplasms

- Optic pathway gliomas*

- Seeding tumors, including any of the following:

- Germ cell tumors (germinomas and nongerminomas)

- Embryonal tumors, including any of the following:

- Medulloblastoma

- Pineoblastoma

- Supratentorial primitive neuroectodermal tumors

- Atypical teratoid/rhabdoid tumor

- Other embryonal tumors NOTE: *Histological requirement waived

- Newly diagnosed disease

- Cerebrospinal fluid (CSF) obtained as part of CSF diversion, initial
diagnosis/staging, or administration of intrathecal chemotherapy (at the initiation
of postoperative therapy)


- Less than 22 years of age


- No prior radiotherapy or chemotherapy

- Prior corticosteroids allowed

Type of Study:


Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Number of IRB approvals of the study

Outcome Description:

IRB approval will be used as a surrogate marker of support for this protocol.

Outcome Time Frame:

Within 120 days of study release

Safety Issue:


Principal Investigator

Brian R. Rood, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Children's Research Institute


United States: Federal Government

Study ID:




Start Date:

August 2006

Completion Date:

Related Keywords:

  • Brain and Central Nervous System Tumors
  • childhood central nervous system germ cell tumor
  • childhood choroid plexus tumor
  • childhood grade I meningioma
  • childhood grade II meningioma
  • childhood grade III meningioma
  • childhood atypical teratoid/rhabdoid tumor
  • untreated childhood visual pathway glioma
  • childhood infratentorial ependymoma
  • childhood supratentorial ependymoma
  • newly diagnosed childhood ependymoma
  • childhood craniopharyngioma
  • untreated childhood medulloblastoma
  • untreated childhood cerebellar astrocytoma
  • untreated childhood supratentorial primitive neuroectodermal tumor
  • untreated childhood brain stem glioma
  • untreated childhood visual pathway and hypothalamic glioma
  • childhood high-grade cerebral astrocytoma
  • childhood low-grade cerebral astrocytoma
  • childhood central nervous system choriocarcinoma
  • childhood central nervous system embryonal tumor
  • childhood central nervous system germinoma
  • childhood central nervous system mixed germ cell tumor
  • childhood central nervous system teratoma
  • childhood central nervous system yolk sac tumor
  • Nervous System Neoplasms
  • Central Nervous System Neoplasms



Children's Hospital of Philadelphia Philadelphia, Pennsylvania  19104
Duke Comprehensive Cancer Center Durham, North Carolina  27710
Dana-Farber Cancer Institute Boston, Massachusetts  02115
Children's National Medical Center Washington, District of Columbia  20010-2970
Children's Hospital of Pittsburgh Pittsburgh, Pennsylvania  15213
Children's Hospital and Regional Medical Center - Seattle Seattle, Washington  98105
Children's Memorial Hospital - Chicago Chicago, Illinois  60614
Texas Children's Cancer Center and Hematology Service at Texas Children's Hospital Houston, Texas  77030-2399