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Gene Expression Profiles in Primary and Metastatic Pancreatic Cancer


N/A
N/A
N/A
Not Enrolling
Both
Pancreatic Cancer

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Trial Information

Gene Expression Profiles in Primary and Metastatic Pancreatic Cancer


OBJECTIVES:

- Compare the gene expression profiles of pancreatic cancer cells from the primary and
metastatic sites in patients with metastatic pancreatic cancer.

- Characterize the function of the differentially upregulated and downregulated genes
identified by comparing the gene expression profiles of primary and metastatic cells in
these patients.

OUTLINE: Fresh biopsy samples are collected for gene expression profiling and other
biomarker/laboratory analyses.

PROJECTED ACCRUAL: A total of 10 patients will be accrued for this study.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of pancreatic adenocarcinoma of exocrine origin

- Metastatic disease

- Fresh biopsy material available from primary site of disease and a metastatic focus,
including liver, peritoneum, or lymph node

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- No prior chemotherapy or radiotherapy for pancreatic cancer

Type of Study:

Observational

Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Outcome Measure:

Gene expression profiles

Outcome Time Frame:

at time of biopsy

Safety Issue:

No

Principal Investigator

Philip A. Philip, MD, PhD, FRCP

Investigator Role:

Study Chair

Investigator Affiliation:

Barbara Ann Karmanos Cancer Institute

Authority:

United States: Federal Government

Study ID:

CDR0000482353

NCT ID:

NCT00897741

Start Date:

December 2004

Completion Date:

March 2009

Related Keywords:

  • Pancreatic Cancer
  • recurrent pancreatic cancer
  • stage IV pancreatic cancer
  • Pancreatic Neoplasms

Name

Location

Barbara Ann Karmanos Cancer InstituteDetroit, Michigan  48201