Gene Expression Profiles in Primary and Metastatic Pancreatic Cancer
N/A
N/A
Both
Pancreatic Cancer
Trial Information
Gene Expression Profiles in Primary and Metastatic Pancreatic Cancer
OBJECTIVES:
- Compare the gene expression profiles of pancreatic cancer cells from the primary and
metastatic sites in patients with metastatic pancreatic cancer.
- Characterize the function of the differentially upregulated and downregulated genes
identified by comparing the gene expression profiles of primary and metastatic cells in
these patients.
OUTLINE: Fresh biopsy samples are collected for gene expression profiling and other
biomarker/laboratory analyses.
PROJECTED ACCRUAL: A total of 10 patients will be accrued for this study.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of pancreatic adenocarcinoma of exocrine origin
- Metastatic disease
- Fresh biopsy material available from primary site of disease and a metastatic focus,
including liver, peritoneum, or lymph node
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- No prior chemotherapy or radiotherapy for pancreatic cancer
Type of Study:
Observational
Study Design:
Observational Model: Case-Only, Time Perspective: Prospective
Outcome Measure:
Gene expression profiles
Outcome Time Frame:
at time of biopsy
Safety Issue:
No
Principal Investigator
Philip A. Philip, MD, PhD, FRCP
Investigator Role:
Study Chair
Investigator Affiliation:
Barbara Ann Karmanos Cancer Institute
Authority:
United States: Federal Government
Study ID:
CDR0000482353
NCT ID:
NCT00897741
Start Date:
December 2004
Completion Date:
March 2009
Related Keywords:
- Pancreatic Cancer
- recurrent pancreatic cancer
- stage IV pancreatic cancer
- Pancreatic Neoplasms
Name | Location |
|---|---|
| Barbara Ann Karmanos Cancer Institute | Detroit, Michigan 48201 |
