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Molecular Fingerprints in Lung Cancer: Predicting Tumor Response to Therapy


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Open (Enrolling)
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Lung Cancer

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Trial Information

Molecular Fingerprints in Lung Cancer: Predicting Tumor Response to Therapy


OBJECTIVES:

- To determine protein and/or RNA expression patterns capable of predicting tumor
response to therapy in tumor tissue samples from patients with lung cancer or suspected
of having lung cancer.

- To characterize the genes and proteins found to be predictive of response in order to
help elucidate the molecular biology underlying cancer chemosensitivity.

OUTLINE: Patients undergo collection of tumor tissue by percutaneous fine needle aspiration,
core biopsy, or during any medically indicated procedure involving removal of lung tissue.
Tissue samples are analyzed by Matrix-assisted laser desorption/ionization time of flight
mass spectrometry (MALDI-MS) and RNA microarrays for protein and gene expression patterns
and for identification of genes and proteins predictive of treatment response. Blood samples
are also collected to obtain normal DNA for analysis.

After completion of study, patients will be followed until their death.

Inclusion Criteria


Inclusion criteria

- Diagnosis of suspected lung cancer or lung cancer

Exclusion criteria

- Inability to undergo therapy

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Protein and/or RNA expression patterns

Outcome Description:

Protein and/or RNA expression patterns in lung tumor tissue that are capable of predicting tumor response to therapy

Outcome Time Frame:

After lung tumor tissue and blood collection.

Safety Issue:

No

Principal Investigator

William Pao, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Vanderbilt-Ingram Cancer Center

Authority:

United States: Vanderbilt University Human Research Protection Program

Study ID:

VICC THO 0547

NCT ID:

NCT00897650

Start Date:

December 2005

Completion Date:

Related Keywords:

  • Lung Cancer
  • lung cancer
  • Lung Neoplasms

Name

Location

Vanderbilt-Ingram Cancer CenterNashville, Tennessee  37232-6838
Vanderbilt-Ingram Cancer Center - Cool SpringsNashville, Tennessee  37064
Vanderbilt-Ingram Cancer Center at FranklinNashville, Tennessee  37064