Trial Information
Treatment Strategy for Low-Grade Gliomas
Inclusion Criteria:
- Histologically confirmed newly diagnosed low-grade gliomas
- Karnofsky performance status of 60 or more
Exclusion Criteria:
- Previous history of radiation therapy or chemotherapy for gliomas
- Pregnant or breast feeding
- Diagnosis of another malignancy may exclude subject from study
- Evidence or history of bleeding diathesis
- Evidence or history of hypersensitivity to temozolomide
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Outcome Measure:
Efficacy of early radiation therapy in MRI-determined total resected LGGs: evaluated as 5-year progression-free survival.
Outcome Time Frame:
10 years
Safety Issue:
No
Principal Investigator
Zhongping Chen, M.D., Ph.D.
Investigator Role:
Study Chair
Investigator Affiliation:
Sun Yat-sen University
Authority:
China: Ministry of Health
Study ID:
YP2008009
NCT ID:
NCT00897377
Start Date:
December 2007
Completion Date:
Related Keywords:
- Astrocytomas
- Oligodendrogliomas
- Oligoastrocytoma
- Astrocytoma
- Oligodendroglioma