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Treatment Strategy for Low-Grade Gliomas


Phase 3
18 Years
60 Years
Open (Enrolling)
Both
Astrocytomas, Oligodendrogliomas, Oligoastrocytoma

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Trial Information

Treatment Strategy for Low-Grade Gliomas


Inclusion Criteria:



- Histologically confirmed newly diagnosed low-grade gliomas

- Karnofsky performance status of 60 or more

Exclusion Criteria:

- Previous history of radiation therapy or chemotherapy for gliomas

- Pregnant or breast feeding

- Diagnosis of another malignancy may exclude subject from study

- Evidence or history of bleeding diathesis

- Evidence or history of hypersensitivity to temozolomide

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Efficacy of early radiation therapy in MRI-determined total resected LGGs: evaluated as 5-year progression-free survival.

Outcome Time Frame:

10 years

Safety Issue:

No

Principal Investigator

Zhongping Chen, M.D., Ph.D.

Investigator Role:

Study Chair

Investigator Affiliation:

Sun Yat-sen University

Authority:

China: Ministry of Health

Study ID:

YP2008009

NCT ID:

NCT00897377

Start Date:

December 2007

Completion Date:

Related Keywords:

  • Astrocytomas
  • Oligodendrogliomas
  • Oligoastrocytoma
  • Astrocytoma
  • Oligodendroglioma

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