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Molecular and Histopathologic Characterization of Atypical Teratoid Rhabdoid Tumors, Choroid Plexus Carcinomas, Ependymomas and Medulloblastoma/PNET of the Pediatric CNS


N/A
N/A
21 Years
Open (Enrolling)
Both
Brain and Central Nervous System Tumors

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Trial Information

Molecular and Histopathologic Characterization of Atypical Teratoid Rhabdoid Tumors, Choroid Plexus Carcinomas, Ependymomas and Medulloblastoma/PNET of the Pediatric CNS


The overall objective of this non-therapeutic protocol is to identify molecular
abnormalities within prospectively treated pediatric CNS Atypical Teratoid Rhabdoid Tumors
(ATRT), Choroid Plexus Carcinomas (CPC), and Ependymoma tumors and define the relationship
between these abnormalities and tumor histologic and clinical characteristics. This
objective will be achieved by applying state-of-the-art DNA, RNA and protein analysis tools
to the study of fresh frozen, fixed and cultured tumor cells. The establishment of cell
cultures from each tumor sample will also allow for in vitro analysis of tumor cell growth,
signaling and therapeutic response.

Inclusion Criteria


Inclusion Criteria

- ATRT, CPC, medulloblastoma/PNET or ependymoma of the CNS as documented by the local
neuropathologist. Tumor may be primary, progressive or relapsed disease.

- Age not more than 21 years at the time of initial diagnosis.

- Enrollment in the current version of the institution's banking protocol

Exclusion Criteria

- Diagnosis other than ATRT, CPC, medulloblastoma/PNET or ependymoma of the central
nervous system.

- Age greater than 21 years at the time of diagnosis

Type of Study:

Observational

Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Outcome Measure:

Relationship between molecular abnormalities and tumor histologic and clinical characteristics

Outcome Time Frame:

10 Years

Safety Issue:

No

Principal Investigator

Amar Gajjar, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

St. Jude Children's Research Hospital

Authority:

United States: Institutional Review Board

Study ID:

NBTP01

NCT ID:

NCT00897286

Start Date:

November 2004

Completion Date:

November 2014

Related Keywords:

  • Brain and Central Nervous System Tumors
  • childhood atypical teratoid/rhabdoid tumor
  • childhood choroid plexus tumor
  • childhood medulloblastoma
  • recurrent childhood medulloblastoma
  • childhood infratentorial ependymoma
  • childhood supratentorial ependymoma
  • recurrent childhood ependymoma
  • recurrent childhood supratentorial primitive neuroectodermal tumor
  • untreated childhood supratentorial primitive neuroectodermal tumor
  • Ependymoma
  • Medulloblastoma
  • Nervous System Neoplasms
  • Central Nervous System Neoplasms
  • Rhabdoid Tumor

Name

Location

St. Jude Children's Research HospitalMemphis, Tennessee  38105-2794