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Plasma Quantification of Cathepsin D and FAS in Non-Small Cell Lung Cancer


N/A
18 Years
N/A
Not Enrolling
Both
Lung Cancer

Thank you

Trial Information

Plasma Quantification of Cathepsin D and FAS in Non-Small Cell Lung Cancer


OBJECTIVES:

- Measure plasma cathepsin D levels in patients with non-small cell lung cancer and in
healthy volunteers using mass spectometry.

- Measure fatty acid synthase levels in these patients and healthy volunteers using mass
spectometry.

OUTLINE: Blood samples are collected from patients and healthy volunteers to measure the
levels of cathepsin D and fatty acid synthase by proteomic profiling and mass spectrometry.


Inclusion Criteria:



Non-Small Cell Lung Cancer Patients

- Documented diagnosis of non-small cell lung cancer, any stage and any time point in
the course of treatment (i.e., at diagnosis, during any treatment, and during post
treatment surveillance)

- Measurable disease by CT scan within the past 4 weeks

Healthy volunteer

- Non-smoking, defined as < 5 packs/year history of smoking and cessation of smoking ≥
6 months ago OR a never smoker

- Not regularly exposed (i.e., daily) to second-hand smoke

Exclusion Criteria:

- Severe underlying lung disease (i.e., chronic obstructive pulmonary disease with
FEV_1 < 1.0 L, pulmonary fibrosis, bronchiectasis, cystic fibrosis, etc.) as
determined by enrolling researcher.

Written consent must be given for both subjects and controls.

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Levels of cathepsin D

Outcome Description:

Measure plasma CD levels in patients with non-small cell lung cancer and non-smoker healthy controls using mass spectrometry.

Outcome Time Frame:

At Routine Follow-Up

Safety Issue:

No

Principal Investigator

Robert A. Kratzke, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Masonic Cancer Center, University of Minnesota

Authority:

United States: Food and Drug Administration

Study ID:

2008NTLS094

NCT ID:

NCT00897234

Start Date:

December 2008

Completion Date:

October 2010

Related Keywords:

  • Lung Cancer
  • recurrent non-small cell lung cancer
  • stage I non-small cell lung cancer
  • stage II non-small cell lung cancer
  • stage IIIA non-small cell lung cancer
  • stage IIIB non-small cell lung cancer
  • stage IV non-small cell lung cancer
  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms

Name

Location
Masonic Cancer Center at University of Minnesota Minneapolis, Minnesota  55455