Health Effects After Leukemia (HEAL) Research Study
- Determine the prevalence of the metabolic syndrome (MS) and its component traits (i.e.,
obesity, hypertension, dyslipidemia, and insulin resistance) in survivors of childhood
acute lymphoblastic leukemia and in healthy sibling volunteers.
- Identify host- and treatment-related risk factors for MS.
OUTLINE: This is a multicenter study.
Patients' medical charts are reviewed and patients undergo anthropometric measuring (height
and weight for BMI calculation and waist and hip circumferences) and blood pressure testing.
Patients also complete questionnaires on their physical activity, diet, and family history
over 30-45 minutes. Blood is collected to measure cytokines (e.g., adiponectin, leptin,
interleukin-6, and C-reactive protein), fasting glucose, and fasting insulin.
Healthy volunteers undergo anthropometric measuring and blood pressure testing (if they are
seen in the clinic). They also complete a baseline medical history and questionnaires on
their physical activity and diet.
Observational Model: Case-Only, Time Perspective: Prospective
Prevalence of the metabolic syndrome (MS) and its component traits in these patients and in healthy volunteers
Jill Simmons, MD
Vanderbilt-Ingram Cancer Center
United States: Federal Government
|Vanderbilt-Ingram Cancer Center||Nashville, Tennessee 37232-6838|
|Vanderbilt-Ingram Cancer Center - Cool Springs||Nashville, Tennessee 37064|