Trial Information
Survival Prediction in HNSCC Based on Gene Expression Profiles From FFPE Tissues
OBJECTIVES:
- Identify gene expression profiles associated with survival by DNA microarray assay
analysis using RNA from formalin-fixed paraffin-embedded tissue samples from patients
with squamous cell carcinoma of the head and neck treated on clinical trial RTOG-9501.
OUTLINE: Formalin-fixed paraffin-embedded tissue samples are analyzed by DNA microarray
analysis for gene expression profiling.
Inclusion Criteria:
- Diagnosis of squamous cell carcinoma of the head and neck, including 1 of the
following sites:
- Hypopharynx
- Larynx
- Oral cavity
- Oropharynx
- Stage II-IV disease
- Must have received treatment on clinical trial RTOG-9501
- Formalin-fixed paraffin-embedded tissue samples available
Exclusion Criteria:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Type of Study:
Observational
Study Design:
Observational Model: Case-Only, Time Perspective: Retrospective
Outcome Measure:
Identification of gene expression profiles used to predict survival as assessed by DNA microarray analysis
Outcome Time Frame:
at time of surgical resection
Safety Issue:
No
Principal Investigator
Barbara Murphy, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Vanderbilt-Ingram Cancer Center
Authority:
United States: Food and Drug Administration
Study ID:
VICC HN 0511
NCT ID:
NCT00897052
Start Date:
February 2005
Completion Date:
December 2007
Related Keywords:
- Head and Neck Cancer
- stage II squamous cell carcinoma of the lip and oral cavity
- stage III squamous cell carcinoma of the lip and oral cavity
- stage IV squamous cell carcinoma of the lip and oral cavity
- stage II squamous cell carcinoma of the oropharynx
- stage III squamous cell carcinoma of the oropharynx
- stage IV squamous cell carcinoma of the oropharynx
- stage II squamous cell carcinoma of the hypopharynx
- stage III squamous cell carcinoma of the hypopharynx
- stage IV squamous cell carcinoma of the hypopharynx
- stage II squamous cell carcinoma of the larynx
- stage III squamous cell carcinoma of the larynx
- stage IV squamous cell carcinoma of the larynx
- Head and Neck Neoplasms