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Survival Prediction in HNSCC Based on Gene Expression Profiles From FFPE Tissues


N/A
18 Years
N/A
Not Enrolling
Both
Head and Neck Cancer

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Trial Information

Survival Prediction in HNSCC Based on Gene Expression Profiles From FFPE Tissues


OBJECTIVES:

- Identify gene expression profiles associated with survival by DNA microarray assay
analysis using RNA from formalin-fixed paraffin-embedded tissue samples from patients
with squamous cell carcinoma of the head and neck treated on clinical trial RTOG-9501.

OUTLINE: Formalin-fixed paraffin-embedded tissue samples are analyzed by DNA microarray
analysis for gene expression profiling.


Inclusion Criteria:



- Diagnosis of squamous cell carcinoma of the head and neck, including 1 of the
following sites:

- Hypopharynx

- Larynx

- Oral cavity

- Oropharynx

- Stage II-IV disease

- Must have received treatment on clinical trial RTOG-9501

- Formalin-fixed paraffin-embedded tissue samples available

Exclusion Criteria:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Type of Study:

Observational

Study Design:

Observational Model: Case-Only, Time Perspective: Retrospective

Outcome Measure:

Identification of gene expression profiles used to predict survival as assessed by DNA microarray analysis

Outcome Time Frame:

at time of surgical resection

Safety Issue:

No

Principal Investigator

Barbara Murphy, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Vanderbilt-Ingram Cancer Center

Authority:

United States: Food and Drug Administration

Study ID:

VICC HN 0511

NCT ID:

NCT00897052

Start Date:

February 2005

Completion Date:

December 2007

Related Keywords:

  • Head and Neck Cancer
  • stage II squamous cell carcinoma of the lip and oral cavity
  • stage III squamous cell carcinoma of the lip and oral cavity
  • stage IV squamous cell carcinoma of the lip and oral cavity
  • stage II squamous cell carcinoma of the oropharynx
  • stage III squamous cell carcinoma of the oropharynx
  • stage IV squamous cell carcinoma of the oropharynx
  • stage II squamous cell carcinoma of the hypopharynx
  • stage III squamous cell carcinoma of the hypopharynx
  • stage IV squamous cell carcinoma of the hypopharynx
  • stage II squamous cell carcinoma of the larynx
  • stage III squamous cell carcinoma of the larynx
  • stage IV squamous cell carcinoma of the larynx
  • Head and Neck Neoplasms

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