Immunoreactivity to Cetuximab in Cancer Patients
N/A
18 Years
75 Years
18 Years
75 Years
Not Enrolling
Both
Colorectal Cancer, Head and Neck Cancer
Both
Colorectal Cancer, Head and Neck Cancer
Trial Information
Immunoreactivity to Cetuximab in Cancer Patients
OBJECTIVES:
- To examine serum samples from patients with head and neck cancer or advanced colorectal
cancer previously treated with cetuximab for the presence of antibodies against
cetuximab.
OUTLINE: Serum samples are examined by immunoreactivity screening of IgE, IgG, IgA, and IgM
antibodies and complement reaction.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Diagnosis of one of the following:
- Head and neck cancer
- Advanced colorectal cancer
- Previously treated with cetuximab
- Serum samples available from patients enrolled in one of the following clinical
trials:
- VU-VICC-GI-0410 (colorectal cancer)
- VU-VICC-GI-0622 (colorectal cancer)
- VU-VICC-HN-0356 (head and neck cancer)
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Type of Study:
Observational
Study Design:
Observational Model: Cohort, Time Perspective: Retrospective
Outcome Measure:
Identification of antibodies (e.g., IgE, IgG, IgA, and IgM) against cetuximab
Outcome Time Frame:
Until all samples are collected.
Safety Issue:
No
Principal Investigator
Barbara Murphy, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Vanderbilt-Ingram Cancer Center
Authority:
United States: Vanderbilt University Human Research Protection Program
Study ID:
VICC HN 0668
NCT ID:
NCT00896896
Start Date:
November 2006
Completion Date:
October 2008
Related Keywords:
- Colorectal Cancer
- Head and Neck Cancer
- stage I squamous cell carcinoma of the hypopharynx
- stage II squamous cell carcinoma of the hypopharynx
- stage III squamous cell carcinoma of the hypopharynx
- stage IV squamous cell carcinoma of the hypopharynx
- recurrent squamous cell carcinoma of the hypopharynx
- stage I squamous cell carcinoma of the larynx
- stage I verrucous carcinoma of the larynx
- stage II squamous cell carcinoma of the larynx
- stage II verrucous carcinoma of the larynx
- stage III squamous cell carcinoma of the larynx
- stage III verrucous carcinoma of the larynx
- stage IV squamous cell carcinoma of the larynx
- stage IV verrucous carcinoma of the larynx
- recurrent squamous cell carcinoma of the larynx
- recurrent verrucous carcinoma of the larynx
- stage I adenoid cystic carcinoma of the oral cavity
- stage I basal cell carcinoma of the lip
- stage I mucoepidermoid carcinoma of the oral cavity
- stage I squamous cell carcinoma of the lip and oral cavity
- stage I verrucous carcinoma of the oral cavity
- stage II adenoid cystic carcinoma of the oral cavity
- stage II basal cell carcinoma of the lip
- stage II mucoepidermoid carcinoma of the oral cavity
- stage II squamous cell carcinoma of the lip and oral cavity
- stage II verrucous carcinoma of the oral cavity
- stage III adenoid cystic carcinoma of the oral cavity
- stage III basal cell carcinoma of the lip
- stage III mucoepidermoid carcinoma of the oral cavity
- stage III squamous cell carcinoma of the lip and oral cavity
- stage III verrucous carcinoma of the oral cavity
- stage IV adenoid cystic carcinoma of the oral cavity
- stage IV basal cell carcinoma of the lip
- stage IV mucoepidermoid carcinoma of the oral cavity
- stage IV squamous cell carcinoma of the lip and oral cavity
- stage IV verrucous carcinoma of the oral cavity
- recurrent adenoid cystic carcinoma of the oral cavity
- recurrent basal cell carcinoma of the lip
- recurrent mucoepidermoid carcinoma of the oral cavity
- recurrent squamous cell carcinoma of the lip and oral cavity
- recurrent verrucous carcinoma of the oral cavity
- metastatic squamous neck cancer with occult primary squamous cell carcinoma
- recurrent metastatic squamous neck cancer with occult primary
- stage I lymphoepithelioma of the nasopharynx
- stage I squamous cell carcinoma of the nasopharynx
- stage II lymphoepithelioma of the nasopharynx
- stage II squamous cell carcinoma of the nasopharynx
- stage III lymphoepithelioma of the nasopharynx
- stage III squamous cell carcinoma of the nasopharynx
- stage IV lymphoepithelioma of the nasopharynx
- stage IV squamous cell carcinoma of the nasopharynx
- recurrent lymphoepithelioma of the nasopharynx
- recurrent squamous cell carcinoma of the nasopharynx
- stage I lymphoepithelioma of the oropharynx
- stage I squamous cell carcinoma of the oropharynx
- stage II lymphoepithelioma of the oropharynx
- stage II squamous cell carcinoma of the oropharynx
- stage III lymphoepithelioma of the oropharynx
- stage III squamous cell carcinoma of the oropharynx
- stage IV lymphoepithelioma of the oropharynx
- stage IV squamous cell carcinoma of the oropharynx
- recurrent lymphoepithelioma of the oropharynx
- stage I esthesioneuroblastoma of the paranasal sinus and nasal cavity
- stage I inverted papilloma of the paranasal sinus and nasal cavity
- stage I midline lethal granuloma of the paranasal sinus and nasal cavity
- stage I squamous cell carcinoma of the paranasal sinus and nasal cavity
- stage II esthesioneuroblastoma of the paranasal sinus and nasal cavity
- stage II inverted papilloma of the paranasal sinus and nasal cavity
- stage II midline lethal granuloma of the paranasal sinus and nasal cavity
- stage II squamous cell carcinoma of the paranasal sinus and nasal cavity
- stage III esthesioneuroblastoma of the paranasal sinus and nasal cavity
- stage III inverted papilloma of the paranasal sinus and nasal cavity
- stage III midline lethal granuloma of the paranasal sinus and nasal cavity
- stage III squamous cell carcinoma of the paranasal sinus and nasal cavity
- stage IV esthesioneuroblastoma of the paranasal sinus and nasal cavity
- stage IV inverted papilloma of the paranasal sinus and nasal cavity
- stage IV midline lethal granuloma of the paranasal sinus and nasal cavity
- stage IV squamous cell carcinoma of the paranasal sinus and nasal cavity
- recurrent esthesioneuroblastoma of the paranasal sinus and nasal cavity
- recurrent inverted papilloma of the paranasal sinus and nasal cavity
- recurrent midline lethal granuloma of the paranasal sinus and nasal cavity
- recurrent squamous cell carcinoma of the paranasal sinus and nasal cavity
- stage I salivary gland cancer
- stage II salivary gland cancer
- stage III salivary gland cancer
- stage IV salivary gland cancer
- recurrent salivary gland cancer
- recurrent squamous cell carcinoma of the oropharynx
- recurrent colon cancer
- stage IV colon cancer
- recurrent rectal cancer
- stage IV rectal cancer
- adenocarcinoma of the colon
- Colorectal Neoplasms
- Head and Neck Neoplasms
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