Effect of Topical Application of Sulforaphane- Containing Broccoli Sprout Extracts on Radiation Dermatitis During External-beam Radiation Therapy for Breast Cancer
- Must have pathologically confirmed invasive adenocarcinoma or ductal carcinoma in
situ of the breast.
- Patients must have undergone segmental mastectomy (i.e., lumpectomy).
- Patients must not have received prior radiation therapy to the breast.
- Patients must not have active local-regional disease prior to registration.
- Patients must not be pregnant because of the potential for fetal harm as a result of
radiation treatment. Women of child-bearing age will be given a serum pregnancy test
prior to study entry to ensure they are not pregnant. They will also be counseled on
the importance of avoiding pregnancy and hormonal contraception while undergoing
- Patients must not have a serious medical or psychiatric illness which prevents
informed consent or compliance with treatment.
- All patients must be informed of the investigational nature of this study and give
written informed consent in accordance with institutional and federal guidelines.
- Visible skin pathology, excessive freckles, or skin blemishes in the test area.
- History of skin disease or hypersensitivity and repeated contact allergies.
- Sarcoma or squamous cell histology.
- Metastatic disease to the breast.
- Current tobacco use.