Aging, Inflammation and Exercise in Chronic Stroke
Many stroke survivors are sedentary and are at risk for the development of diabetes. We
will study the interactions of adipose tissue and the paretic and non-paretic muscle
inflammation, insulin signaling and action in hemiparetic stroke patients and the ability to
employ exercise training to reverse these abnormalities in this ethnically diverse
population. Participants aged 40-75 years with chronic stroke will be randomized to
treadmill training versus stretch control group using a one-two-one blocked randomization on
race (black vs. white), sex (male vs. female), and glucose tolerance status (normal vs.
impaired and type 2 diabetes).
Stroke occurs in over 780,000 persons each year in the U.S., the vast majority reported in
persons older than 55 years of age. Following stroke, patients remain at continued high risk
for recurrent stroke. Inflammatory processes lead to cardiovascular events/stroke and
contribute to disease risk progression by impacting insulin resistance and the development
of type 2 diabetes. Interventions that reduce inflammation and improve insulin sensitivity
have important clinical implications, especially in the stroke population.
Task-oriented treadmill training is utilized to improve cardiovascular fitness and
functional mobility in hemiparetic stroke patients. Additionally, preliminary data indicates
that progressive treadmill training in this population improves glucose tolerance.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
TNFalpha (tumor necrosis factor alpha), adiponectin in adipose tissue and skeletal muscle
Baseline and 6 months
Alice S. Ryan, PhD
University of Maryland, VA Research Service
United States: Federal Government
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