Inclusion Criteria

INCLUSION CRITERIA:

The patient must meet the following eligibility inclusion criteria at the time of
PROCUREMENT:

1. Diagnosis of advanced stage* or metastatic HER2-positive cancer (Immunohistochemistry
or RT-PCR is used to determine HER2 positivity)

Definitions of Malignancies and Advanced Stages:

Breast ≥Stage IIIb Colon cancer ≥Stage IIIb Esophageal cancer ≥Stage IIIb Gastric
carcinoma ≥Stage IIIb Head and Neck cancer Stage IV Lung cancer ≥Stage IIIb
Pancreatic cancer Stage IV Prostate cancer Stage IV

*it is expected that the majority of patients who will be accrued on the protocol
will have one of the HER2-positive malignancies listed in the table. If the patient's
malignancy is not listed we will use ≥ Stage IIIb as the definition of advanced stage
disease. If Stage IIIb is not part of the staging system for the individual tumor,
Stage IV will be used.

For GBM (Glioblastoma, WHO grade IV):patients will be eligible, who have recurrent or
progressive disease after front line therapy.

2. Karnofsky/Lansky score of 50 or more

3. EBV seropositive

4. Greater than or equal to 3 years old

5. Informed consent explained to, understood by and signed by patient/guardian.
Patient/guardian given copy of informed consent.

The patient must meet the following eligibility criteria to be included for TREATMENT:

1. Diagnosis of advanced stage* or metastatic HER2-positive cancer with disease
progressed after receiving at least one prior systemic therapy. (Immunohistochemistry
or RT-PCR is used to determine HER2 positivity) *for definition refer to Table above.

2. Greater than or equal to 3 years old.

3. EBV-seropositive

4. Recovered from the acute toxic effects of all prior chemotherapy at least a week
before entering this study.

5. Normal ECHO (Left ventricular ejection fraction (LVEF) has to be with in normal,
institutional limits)

5. Life expectancy 6 weeks or more

7. Karnofsky/Lansky score of 50 or more

8. Bilirubin 3x or less, AST 5x or less, Serum creatinine 2x upper limit of normal or
less, Hgb 9.0 g/dl or more, WBC greater than 2,000/ul, ANC greater than 1,000/ul,
Platelets greater than 100,000/ul

9. Pulse oximetry 90% or more on room air

10. Sexually active patients must be willing to utilize one of the more effective birth
control methods for 6 months after the CTL infusion. Male partner should use a condom.
Acceptable forms of birth control include: * oral contraceptives ("the pill"), *
intrauterine devices (IUDs), * contraceptive implants under the skin, or contraceptive
injections, * condoms with foam.

11. Available autologous transduced EBV-specific cytotoxic T lymphocytes with 15% or more
expression of HER2 CAR determined by flow-cytometry and killing of Her2-positive targets
20% or more in cytotoxicity assay.

12. Informed consent explained to, understood by and signed by patient/guardian.
Patient/guardian given copy of informed consent

Note: Patients must also not receive antineoplastic drugs while on this study since they
would kill the infused T cells.

EXCLUSION CRITERIA:

At time of Procurement:

1. Known HIV positivity

At time of Treatment:

1. Severe intercurrent infection

2. Known HIV positivity

3. Pregnant or lactating

4. History of hypersensitivity reactions to murine protein-containing products