Inclusion Criteria:

- premenopausal women ≥ 18 years

- diagnosis of PCOS based on the recent 2006 Androgen Excess Society criteria (modified
from Rotterdam 2003)

- waist circumference >88 cm

- fasting TG 2.0 - 5.0 mmol/L

- stable on any type of oral contraceptive for a minimum of 3-months

Exclusion Criteria:

- known contraindications for MRI

- pregnancy, lactation, desire to become pregnant

- participation in another clinical trial

- fasting TF level ≥ 5.0 mmol/L

- AST or ALT > 2.5 times upper limit of normal (ULN)

- creatinine kinase (CK) > 6x ULN

- creatinine > 115 μmol/L

- fasting glucose ≥ 7.0 mmol/L and/or 2h glucose post oral glucose tolerance test
(OGTT) ≥ 11.1 mmol/L or personal history of DM2

- personal history of renal disease, liver disease (except NAFLD), or heart disease

- body mass index (BMI) < 18 or > 40 kg/m²

- increased alcohol use (>9 standard drinks per week [standard drink = 12oz beer, 5oz
wine, or 1.5oz spirits]) or drug use

- use of other hormonal contraception, growth hormone, glucocorticoids,
anti-diabetic/anti-dyslipidemia medications, or anabolic steroids.